Mouse PHD Finger Protein 8 (PHF8) ELISA Kit
715€ (96 tests)
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935106861
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name
Mouse PHD Finger Protein 8 (PHF8) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx154539
tested applications
ELISA
Description
Mouse PHD Finger Protein 8 (PHF8) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Mouse PHD Finger Protein 8 (PHF8) concentrations in tissue homogenates and other biological fluids. This assay has high sensitivity and excellent specificity for detection of PHD Finger Protein 8 (PHF8)
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | ELISA Kits |
| Immunogen Target | PHD Finger Protein 8 (PHF8) |
| Reactivity | Mouse |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 0.312 ng/ml - 20 ng/ml |
| Sensitivity | < 0.12 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Size 2 | 5 × 96 tests |
| Size 3 | 10 × 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates and other biological fluids. |
| Availability | Shipped within 5-7 working days. The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| Alias | JHDM1F,KDM7B MRXSSD,ZNF422,Histone lysine demethylase PHF8 |
| Background | Elisa kits for PHF8 |
| Status | RUO |
| Note | Validity: The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
PHF8 is a histone demethylase containing a PHD finger domain that recognizes H3K4me3 and demethylates repressive marks such as H3K9me2/1 to activate transcription. It plays a role in gene regulation during cell cycle progression, neuronal development, and DNA damage repair by promoting chromatin accessibility. PHF8 is expressed in neural tissues and contributes to neurogenesis, synaptic plasticity, and cognitive function. Mutations in PHF8 are associated with X-linked intellectual disability and cleft lip/palate syndromes, where impaired histone demethylation leads to defective gene expression during development. Dysregulation of PHF8 is also implicated in cancer, where it promotes tumor growth and proliferation through transcriptional activation of oncogenes. Knockdown studies demonstrate impaired DNA repair, cell cycle arrest, and defects in neuronal differentiation, highlighting its critical role in histone demethylation, chromatin regulation, and developmental processes.
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