PHD Finger Protein 21B (PHF21B) Antibody
195€ (20 µl)
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935106861
info@markelab.com
name
PHD Finger Protein 21B (PHF21B) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx006556
tested applications
ELISA, WB
Description
PHF21B Antibody is a Rabbit Polyclonal Antibody against PHF21B.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | PHD Finger Protein 21B (PHF21B) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | ELISA: 1 µg/ml, WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 20 µl |
| Size 2 | 100 µl |
| Size 3 | 2 × 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q96EK2 |
| Gene ID | 112885 |
| NCBI Accession | NP_612424.1 |
| Alias | PHF21B,KIAA1661,BHC80L,PHF4 |
| Background | Antibody anti-PHF21B |
| Status | RUO |
| Note | Concentration: > 0.2 mg/ml - |
Descripción
PHF21B is a chromatin-binding protein containing a PHD domain, which recognizes and interacts with methylated histones to regulate transcriptional activation or repression. It is involved in chromatin remodeling and modulating gene expression programs linked to cellular proliferation, differentiation, and tumor suppression. PHF21B is expressed in epithelial tissues and immune cells, where it controls pathways involved in cell cycle progression and immune responses. Emerging evidence suggests that PHF21B plays a role in tumor suppression by stabilizing chromatin architecture and regulating oncogene expression. Dysregulation of PHF21B has been implicated in cancers, including breast and colorectal cancer, where its loss of function leads to uncontrolled cell proliferation and genomic instability. Functional studies demonstrate defects in transcriptional repression, impaired chromatin organization, and increased oncogenic signaling, underscoring its role as a critical regulator of epigenetic control and tumor suppression.
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