PHD Finger Protein 21B (PHF21B) Antibody

Background

PHF21B is a chromatin-binding protein containing a PHD domain, which recognizes and interacts with methylated histones to regulate transcriptional activation or repression. It is involved in chromatin remodeling and modulating gene expression programs linked to cellular proliferation, differentiation, and tumor suppression. PHF21B is expressed in epithelial tissues and immune cells, where it controls pathways involved in cell cycle progression and immune responses. Emerging evidence suggests that PHF21B plays a role in tumor suppression by stabilizing chromatin architecture and regulating oncogene expression. Dysregulation of PHF21B has been implicated in cancers, including breast and colorectal cancer, where its loss of function leads to uncontrolled cell proliferation and genomic instability. Functional studies demonstrate defects in transcriptional repression, impaired chromatin organization, and increased oncogenic signaling, underscoring its role as a critical regulator of epigenetic control and tumor suppression.