PHD Finger Protein 20-Like Protein 1 (PHF20L1) Antibody

Background

PHF20L1 is a chromatin-binding protein with a PHD finger domain that recognizes methylated histones, particularly H3K4me3, and contributes to transcriptional regulation and chromatin organization. It functions as a transcriptional co-activator or repressor depending on the cellular context and modulates gene expression programs during development and proliferation. PHF20L1 is associated with the regulation of pluripotency, differentiation, and DNA repair, where it stabilizes chromatin architecture and facilitates the recruitment of histone-modifying complexes. It is widely expressed in proliferative and stem cell-rich tissues, playing roles in maintaining genomic stability and epigenetic regulation. Dysregulation of PHF20L1 has been implicated in cancers and neurodevelopmental disorders due to impaired gene regulation and histone recognition. Knockdown studies reveal defects in gene expression, reduced chromatin stability, and impaired cellular differentiation, underscoring its role in transcriptional control and epigenetic regulation.