PHD Finger Protein 13 (PHF13) Antibody
357.5€ (100 µg)
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935106861
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name
PHD Finger Protein 13 (PHF13) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx036836
tested applications
ELISA, WB
Description
Rabbit Polyclonal against the PHF13 protein.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | PHD Finger Protein 13 (PHF13) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | ELISA: 1/20000 - 1/80000, WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by antigen affinity column chromatography. |
| Size 1 | 100 µg |
| Size 2 | 1 mg |
| Form | Lyophilized |
| Tested Applications | ELISA, WB |
| Buffer | Prior to lyophilization: 1% BSA and 0.02% NaN3. |
| Availability | Shipped within 7-15 working days. |
| Storage | Store at -20 °C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | PHF12, KIAA1523,PHD factor 1,PF1 |
| Background | Antibody anti-PHF13 |
| Status | RUO |
| Note | Concentration: Lyophilized form: Not applicable. After reconstitution: 1 mg/ml. - |
Descripción
PHF13 is a chromatin-binding protein with a PHD finger domain that recognizes methylated histone residues, particularly H3K4me3, to regulate transcriptional activation and chromatin accessibility. It functions as a transcriptional co-activator, recruiting chromatin remodelers and transcription machinery to active gene loci. PHF13 is involved in processes such as DNA repair, cellular differentiation, and the regulation of pluripotency genes in embryonic stem cells. It is expressed in various tissues, including hematopoietic and neural lineages, where it modulates lineage-specific gene expression programs. Dysregulation of PHF13 has been associated with impaired DNA damage response, developmental defects, and tumorigenesis, where altered chromatin dynamics affect cellular proliferation and survival. Knockout studies demonstrate reduced transcriptional activation, defective chromatin remodeling, and impaired cellular differentiation, underscoring its role in maintaining transcriptional fidelity and chromatin structure during development and stress responses.
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