PHD Finger Protein 13 (PHF13) Antibody
312€ (60 µl)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
935106861
info@markelab.com
name
PHD Finger Protein 13 (PHF13) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx006040
tested applications
WB
Description
PHF13 Antibody is a Rabbit Polyclonal Antibody against PHF13.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | PHD Finger Protein 13 (PHF13) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 60 µl |
| Size 2 | 120 µl |
| Size 3 | 200 µl |
| Form | Liquid |
| Tested Applications | WB |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q86YI8 |
| Gene ID | 148479 |
| NCBI Accession | NP_722519.2 |
| Alias | PHF12, KIAA1523,PHD factor 1,PF1 |
| Background | Antibody anti-PHF13 |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
PHF13 is a chromatin-binding protein with a PHD finger domain that recognizes methylated histone residues, particularly H3K4me3, to regulate transcriptional activation and chromatin accessibility. It functions as a transcriptional co-activator, recruiting chromatin remodelers and transcription machinery to active gene loci. PHF13 is involved in processes such as DNA repair, cellular differentiation, and the regulation of pluripotency genes in embryonic stem cells. It is expressed in various tissues, including hematopoietic and neural lineages, where it modulates lineage-specific gene expression programs. Dysregulation of PHF13 has been associated with impaired DNA damage response, developmental defects, and tumorigenesis, where altered chromatin dynamics affect cellular proliferation and survival. Knockout studies demonstrate reduced transcriptional activation, defective chromatin remodeling, and impaired cellular differentiation, underscoring its role in maintaining transcriptional fidelity and chromatin structure during development and stress responses.
Related Products
Recombinant Human PHF13
Ver Producto
PHD Finger Protein 13 (PHF13) Antibody
PHF13 Antibody is a Rabbit Polyclonal Antibody against PHF13.
Ver Producto
PHD Finger Protein 13 (PHF13) Antibody
PHF13 contains 1 PHD-type zinc finger. The function of PHF13 is currently unknown.
Ver Producto