PHD Finger Protein 12 (PHF12) Antibody

Este producto es parte de PHF - PHD finger protein
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364€ (100 µg)

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935106861
info@markelab.com
name
PHD Finger Protein 12 (PHF12) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx236379
tested applications
ELISA, WB

Description

PHF12 Antibody is a Rabbit Polyclonal against PHF12.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Primary Antibodies
Immunogen Target
PHD Finger Protein 12 (PHF12)
Host
Rabbit
Reactivity
Human, Mouse
Recommended Dilution
WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
Clonality
Polyclonal
Conjugation
Unconjugated
Isotype
IgG
Purity
≥ 95% (SDS-PAGE)
Purification
Purified by immunogen affinity chromatography.
Size 1
100 µg
Form
Liquid
Tested Applications
ELISA, WB
Buffer
PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol.
Availability
Shipped within 5-12 working days.
Storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
Q96QT6
OMIM
618645
Alias
PHF12, KIAA1523,PHD factor 1,PF1
Background
Antibody anti-PHF12
Status
RUO
Note
Concentration: 2 mg/ml - Validity: 12 months.

Descripción

PHF12 is a transcriptional co-repressor and chromatin-associated protein that contains a PHD domain, which enables it to bind methylated histones, particularly H3K4me2/3. PHF12 is a component of the Sin3A-HDAC complex, which regulates gene expression by promoting histone deacetylation and chromatin condensation. It plays an important role in transcriptional repression, DNA damage repair, and cellular differentiation by silencing specific genes during development. PHF12 is highly expressed in tissues undergoing epigenetic remodeling, such as embryonic stem cells and neuronal tissues, where it modulates processes like neurogenesis and stem cell maintenance. Dysregulation of PHF12 has been linked to developmental abnormalities, neurological disorders, and cancers due to aberrant histone modification and transcriptional repression. Knockdown studies reveal defects in gene silencing, impaired chromatin remodeling, and disrupted differentiation, highlighting its role as a critical regulator of chromatin dynamics and transcriptional control.

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