PHD Finger Protein 12 (PHF12) Antibody
377€ (100 µg)
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Name
PHD Finger Protein 12 (PHF12) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx236379
Tested Applications
ELISA, WB
Description
PHF12 Antibody is a Rabbit Polyclonal against PHF12.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: PHD Finger Protein 12 (PHF12) Immunogen: PHD finger protein 12 |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Assay Type | Concentration: 2 mg/ml |
| Recommended Dilution | WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | Observed MW: 110-120 kDa |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by immunogen affinity chromatography. |
| Size 1 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q96QT6 |
| OMIM | 618645 |
| Alias | PHF12, KIAA1523,PHD factor 1,PF1 |
| Background | Antibody anti-PHF12 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
PHF12 is a transcriptional co-repressor and chromatin-associated protein that contains a PHD domain, which enables it to bind methylated histones, particularly H3K4me2/3. PHF12 is a component of the Sin3A-HDAC complex, which regulates gene expression by promoting histone deacetylation and chromatin condensation. It plays an important role in transcriptional repression, DNA damage repair, and cellular differentiation by silencing specific genes during development. PHF12 is highly expressed in tissues undergoing epigenetic remodeling, such as embryonic stem cells and neuronal tissues, where it modulates processes like neurogenesis and stem cell maintenance. Dysregulation of PHF12 has been linked to developmental abnormalities, neurological disorders, and cancers due to aberrant histone modification and transcriptional repression. Knockdown studies reveal defects in gene silencing, impaired chromatin remodeling, and disrupted differentiation, highlighting its role as a critical regulator of chromatin dynamics and transcriptional control.
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