Human PHD finger protein 12 (PHF12) ELISA Kit
715€ (96 tests)
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name
Human PHD finger protein 12 (PHF12) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx538650
tested applications
ELISA
Description
Human PHD finger protein 12 (PHF12) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human PHD finger protein 12 (PHF12) concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | ELISA Kits |
| Immunogen Target | PHD finger protein 12 (PHF12) |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-15 working days. The validity for this kit is 6 months. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | Q96QT6 |
| OMIM | 618645 |
| Alias | PHF12, KIAA1523,PHD factor 1,PF1 |
| Background | Elisa kits for PHF12 |
| Status | RUO |
| Note | Validity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
PHF12 is a transcriptional co-repressor and chromatin-associated protein that contains a PHD domain, which enables it to bind methylated histones, particularly H3K4me2/3. PHF12 is a component of the Sin3A-HDAC complex, which regulates gene expression by promoting histone deacetylation and chromatin condensation. It plays an important role in transcriptional repression, DNA damage repair, and cellular differentiation by silencing specific genes during development. PHF12 is highly expressed in tissues undergoing epigenetic remodeling, such as embryonic stem cells and neuronal tissues, where it modulates processes like neurogenesis and stem cell maintenance. Dysregulation of PHF12 has been linked to developmental abnormalities, neurological disorders, and cancers due to aberrant histone modification and transcriptional repression. Knockdown studies reveal defects in gene silencing, impaired chromatin remodeling, and disrupted differentiation, highlighting its role as a critical regulator of chromatin dynamics and transcriptional control.
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