Paired Box Protein Pax-2 (PAX2) Antibody
312€ (60 µl)
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935106861
info@markelab.com
name
Paired Box Protein Pax-2 (PAX2) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx002211
tested applications
IF/ICC
Description
PAX2 Antibody is a Rabbit Polyclonal antibody against PAX2. This gene encodes type I adenylate cyclase activating polypeptide receptor, which is a membrane-associated protein and shares significant homology with members of the glucagon/secretin receptor family. This receptor mediates diverse biological actions of adenylate cyclase activating polypeptide 1 and is positively coupled to adenylate cyclase. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Paired Box Protein Pax-2 (PAX2) |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 60 µl |
| Size 2 | 120 µl |
| Size 3 | 200 µl |
| Form | Liquid |
| Tested Applications | IF/ICC |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q02962 |
| Gene ID | 5076 |
| NCBI Accession | NP_003978.3 |
| Alias | FSGS7,PAPRS,PAX-2 |
| Background | Antibody anti-PAX2 |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
PAX2 is a transcription factor that plays a crucial role in the development of the urogenital system, central nervous system, and the optic nerve by regulating cell proliferation, differentiation, and survival. PAX2 is highly expressed during nephrogenesis, where it guides the formation of kidney structures, including the ureteric bud and nephrons, and in optic development, where it contributes to retinal and optic nerve patterning. Mutations in PAX2 are linked to renal coloboma syndrome, characterized by kidney malformations, optic nerve hypoplasia, and hearing loss. PAX2 also functions as an oncogene in cancers such as renal cell carcinoma and ovarian cancer, where its aberrant expression promotes cell survival, proliferation, and resistance to apoptosis. Knockout studies in mice reveal impaired kidney development, absent optic nerves, and embryonic lethality, highlighting PAX2's essential roles in organogenesis, tissue morphogenesis, and cell lineage specification.
Related Products
Paired Box Protein Pax-2 (PAX2) Antibody
PAX2 Antibody is a Rabbit Polyclonal antibody against PAX2. This gene encodes type I adenylate cyclase activating polypeptide receptor, which is a membrane-associated protein and shares significant homology with members of the glucagon/secretin receptor family. This receptor mediates diverse biological actions of adenylate cyclase activating polypeptide 1 and is positively coupled to adenylate cyclase. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified.
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