Paired Box 2 (PAX2) Antibody
357.5€ (100 µg)
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935106861
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name
Paired Box 2 (PAX2) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx038407
tested applications
ELISA, WB
Description
Rabbit Polyclonal against the PAX2 protein.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Paired Box 2 (PAX2) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | ELISA: 1/20000 - 1/80000, WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by Protein A/G column chromatography. |
| Size 1 | 100 µg |
| Size 2 | 1 mg |
| Form | Lyophilized |
| Tested Applications | ELISA, WB |
| Buffer | Prior to lyophilization: 0.02% NaN3. |
| Availability | Shipped within 7-15 working days. |
| Storage | Store at -20 °C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| NCBI Accession | NM_003988 |
| Alias | FSGS7,PAPRS,PAX-2 |
| Background | Antibody anti-PAX2 |
| Status | RUO |
| Note | Concentration: Lyophilized form: Not applicable. After reconstitution: 1 mg/ml. - |
Descripción
PAX2 is a transcription factor that plays a crucial role in the development of the urogenital system, central nervous system, and the optic nerve by regulating cell proliferation, differentiation, and survival. PAX2 is highly expressed during nephrogenesis, where it guides the formation of kidney structures, including the ureteric bud and nephrons, and in optic development, where it contributes to retinal and optic nerve patterning. Mutations in PAX2 are linked to renal coloboma syndrome, characterized by kidney malformations, optic nerve hypoplasia, and hearing loss. PAX2 also functions as an oncogene in cancers such as renal cell carcinoma and ovarian cancer, where its aberrant expression promotes cell survival, proliferation, and resistance to apoptosis. Knockout studies in mice reveal impaired kidney development, absent optic nerves, and embryonic lethality, highlighting PAX2's essential roles in organogenesis, tissue morphogenesis, and cell lineage specification.
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