P2Y Purinoceptor 14 (P2RY14) Antibody
364€ (100 µg)
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935106861
info@markelab.com
name
P2Y Purinoceptor 14 (P2RY14) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx233588
tested applications
ELISA, IHC
Description
GPR105 Antibody is a Rabbit Polyclonal against GPR105.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | P2Y Purinoceptor 14 (P2RY14) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | IHC: 1/20 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by immunogen affinity chromatography. |
| Size 1 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, IHC |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q15391 |
| Alias | P2RY14,G protein coupled receptor for UDP-glucose,G protein-coupled receptor 105,GPR105,P2Y purinoceptor 14,G-protein coupled receptor 105,purinergic receptor P2Y,BPR105,P2Y14 |
| Background | Antibody anti-P2RY14 |
| Status | RUO |
| Note | Concentration: 2 mg/ml - Validity: 12 months. |
Descripción
P2RY14 is a G protein-coupled receptor activated by UDP-sugars, such as UDP-glucose and UDP-galactose. P2RY14 primarily couples to Gi/o proteins, inhibiting adenylate cyclase, reducing cAMP levels, and modulating inflammatory and immune responses. P2RY14 is widely expressed in immune cells, including neutrophils, macrophages, and lymphocytes, as well as in the gastrointestinal tract and central nervous system. It plays a critical role in innate immunity by mediating chemotaxis, cytokine production, and immune cell recruitment during inflammation and infection. In the gastrointestinal system, P2RY14 is involved in mucus production and epithelial repair. Dysregulation of P2RY14 is associated with inflammatory diseases, immune dysfunction, and metabolic disorders. P2RY14 is emerging as a therapeutic target for conditions like asthma, diabetes, and gastrointestinal inflammation, where modulation of UDP-sugar signaling can improve immune regulation and tissue homeostasis.
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