Human P2Y Purinoceptor 13 (P2RY14) Protein

Este producto es parte de P2RY  - Purinergic Receptor P2Y
Human P2Y Purinoceptor 13 (P2RY14) Protein

Pida mas información

935106861

info@markelab.com

Precio

234€ (10 µg)

Protein P2RY14

proveedor

Abbexa

reference

abx068792

Tested Applications

WB, SDS-PAGE

reactivity

status

RUO

clonality

Descripción

Recombinant Purinergic Receptor P2Y, G Protein Coupled 14 (P2RY14) is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).


Background

P2RY14 is a G protein-coupled receptor activated by UDP-sugars, such as UDP-glucose and UDP-galactose. P2RY14 primarily couples to Gi/o proteins, inhibiting adenylate cyclase, reducing cAMP levels, and modulating inflammatory and immune responses. P2RY14 is widely expressed in immune cells, including neutrophils, macrophages, and lymphocytes, as well as in the gastrointestinal tract and central nervous system. It plays a critical role in innate immunity by mediating chemotaxis, cytokine production, and immune cell recruitment during inflammation and infection. In the gastrointestinal system, P2RY14 is involved in mucus production and epithelial repair. Dysregulation of P2RY14 is associated with inflammatory diseases, immune dysfunction, and metabolic disorders. P2RY14 is emerging as a therapeutic target for conditions like asthma, diabetes, and gastrointestinal inflammation, where modulation of UDP-sugar signaling can improve immune regulation and tissue homeostasis.

Características del producto

category

Proteins and Peptides


origin

Human


host

E. coli


immunogen target

P2Y Purinoceptor 13 (P2RY14)


host

E. coli


conjugation

Unconjugated


form

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.


tested applications

WB, SDS-PAGE


size 1

10 µg


size 2

50 µg


size 3

100 µg


size 4

200 µg


size 5

500 µg


observerd MW

Molecular Weight: Calculated MW: 33.0 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Pro51-Arg303 Tag: N-terminal His tag


expression

Recombinant


purity

> 95%


buffer

Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.


storage

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.


or code

P2RY14


dry ice

No


availability

Shipped within 5-7 working days.


alias

P2RY14,G protein coupled receptor for UDP-glucose,G protein-coupled receptor 105,GPR105,P2Y purinoceptor 14,G-protein coupled receptor 105,purinergic receptor P2Y,BPR105,P2Y14


note

This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.


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