Human P2Y Purinoceptor 13 (P2RY14) Protein
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935106861
info@markelab.com
Precio
234€ (10 µg)
Protein P2RY14
proveedor
Abbexareference
abx068792Tested Applications
WB, SDS-PAGEreactivity
status
RUOclonality
Descripción
Recombinant Purinergic Receptor P2Y, G Protein Coupled 14 (P2RY14) is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).
Background
P2RY14 is a G protein-coupled receptor activated by UDP-sugars, such as UDP-glucose and UDP-galactose. P2RY14 primarily couples to Gi/o proteins, inhibiting adenylate cyclase, reducing cAMP levels, and modulating inflammatory and immune responses. P2RY14 is widely expressed in immune cells, including neutrophils, macrophages, and lymphocytes, as well as in the gastrointestinal tract and central nervous system. It plays a critical role in innate immunity by mediating chemotaxis, cytokine production, and immune cell recruitment during inflammation and infection. In the gastrointestinal system, P2RY14 is involved in mucus production and epithelial repair. Dysregulation of P2RY14 is associated with inflammatory diseases, immune dysfunction, and metabolic disorders. P2RY14 is emerging as a therapeutic target for conditions like asthma, diabetes, and gastrointestinal inflammation, where modulation of UDP-sugar signaling can improve immune regulation and tissue homeostasis.
Características del producto
category
Proteins and Peptides
origin
Human
host
E. coli
immunogen target
P2Y Purinoceptor 13 (P2RY14)
host
E. coli
conjugation
Unconjugated
form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
tested applications
WB, SDS-PAGE
size 1
10 µg
size 2
50 µg
size 3
100 µg
size 4
200 µg
size 5
500 µg
observerd MW
Molecular Weight: Calculated MW: 33.0 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Pro51-Arg303 Tag: N-terminal His tag
expression
Recombinant
purity
> 95%
buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
or code
P2RY14
dry ice
No
availability
Shipped within 5-7 working days.
alias
P2RY14,G protein coupled receptor for UDP-glucose,G protein-coupled receptor 105,GPR105,P2Y purinoceptor 14,G-protein coupled receptor 105,purinergic receptor P2Y,BPR105,P2Y14
uniprot id
note
This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.
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