P2Y Purinoceptor 13 (P2RY13) Antibody
383.5€ (100 µl)
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935106861
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name
P2Y Purinoceptor 13 (P2RY13) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx015951
tested applications
ELISA, FCM
Description
The product of this gene belongs to the family of G-protein coupled receptors.This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides.This receptor is activated by ADP.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | P2Y Purinoceptor 13 (P2RY13) |
| Host | Mouse |
| Reactivity | Human |
| Recommended Dilution | ELISA: 1/10000, FCM: 1/200 - 1/400. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG1 |
| Purification | Unpurified ascites. |
| Size 1 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, FCM |
| Buffer | Ascitic fluid containing 0.03% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9BPV8 |
| Gene ID | 53829 |
| OMIM | 606380 |
| Alias | P2RY13,GPR94,G protein-coupled receptor 86,P2Y purinoceptor 13, purinergic receptor P2Y G-protein coupled 13,purinergic receptor P2Y,FKSG77,GPCR1,GPR86,P2Y13,SP174 |
| Background | Antibody anti-P2RY13 |
| Status | RUO |
| Note | Concentration: Not determined. - |
Descripción
P2RY13 is a G protein-coupled receptor primarily activated by ADP and related nucleotides. It couples to Gi proteins, inhibiting adenylate cyclase, reducing cAMP levels, and modulating downstream cellular responses. P2RY13 is expressed in immune cells, liver, and the central nervous system, where it regulates lipid metabolism, immune responses, and energy homeostasis. In the liver, P2RY13 plays a key role in cholesterol metabolism by mediating the uptake of high-density lipoproteins (HDL), contributing to cholesterol homeostasis. In immune cells, P2RY13 regulates chemotaxis, cytokine production, and inflammation. Dysregulation of P2RY13 has been linked to lipid disorders, atherosclerosis, and inflammatory diseases. Its role in immune and metabolic regulation makes P2RY13 a promising therapeutic target for managing hyperlipidemia, atherosclerosis, and chronic inflammatory conditions. Understanding its signaling mechanisms could provide novel therapeutic avenues for metabolic and immune-related diseases.
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