Oxoeicosanoid Receptor 1 (OXER1) Antibody (FITC)
169€ (20 µg)
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935106861
info@markelab.com
name
Oxoeicosanoid Receptor 1 (OXER1) Antibody (FITC)
category
Primary Antibodies
provider
Abbexa
reference
abx336899
Description
OXER1 Antibody (FITC) is a Rabbit Polyclonal against OXER1.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Oxoeicosanoid Receptor 1 (OXER1) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | FITC |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G. |
| Size 1 | 20 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid exposure to light. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q8TDS5 |
| Gene ID | 165140 |
| Alias | OXER1,GPCR,GPR170,TG1019,hGPCR48,R527,5-oxo-ETE receptor,oxoeicosanoid (OXE) receptor 1 |
| Background | Antibody anti-OXER1 |
| Status | RUO |
Descripción
OXER1, also known as the 5-oxo-ETE receptor, is a G protein-coupled receptor activated by 5-oxo-eicosatetraenoic acid (5-oxo-ETE), a bioactive lipid derived from arachidonic acid metabolism. OXER1 is expressed primarily in leukocytes, including eosinophils, neutrophils, and macrophages, where it mediates pro-inflammatory and chemotactic responses. Activation of OXER1 triggers pathways such as PI3K/Akt and MAPK, promoting immune cell migration, cytokine production, and oxidative stress responses. OXER1 plays a crucial role in allergic inflammation, asthma, and other eosinophilic diseases, where it contributes to immune cell recruitment to inflamed tissues. In cancer, OXER1 is implicated in tumor progression and metastasis, particularly in prostate and breast cancers, where 5-oxo-ETE signaling enhances cell proliferation and survival. Dysregulation of OXER1 has also been associated with cardiovascular diseases and chronic inflammatory conditions. Given its roles in inflammation and cancer, OXER1 is considered a promising therapeutic target for managing eosinophilic disorders, chronic inflammation, and tumor progression.
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