Oxoeicosanoid Receptor 1 (OXER1) Antibody
377€ (100 µg)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Name
Oxoeicosanoid Receptor 1 (OXER1) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx236052
Tested Applications
ELISA, WB, IHC, FCM
Description
OXER1 Antibody is a Rabbit Polyclonal against OXER1.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Oxoeicosanoid Receptor 1 (OXER1) Immunogen: oxoeicosanoid(OXE) receptor 1 |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Assay Type | Concentration: 2 mg/ml |
| Recommended Dilution | WB: 1/500 - 1/2000, IHC: 1/20 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | Observed MW: 43-46 kDa |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by immunogen affinity chromatography. |
| Size 1 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC, FCM |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q8TDS5 |
| Gene ID | 165140 |
| Alias | OXER1,GPCR,GPR170,TG1019,hGPCR48,R527,5-oxo-ETE receptor,oxoeicosanoid (OXE) receptor 1 |
| Background | Antibody anti-OXER1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
OXER1, also known as the 5-oxo-ETE receptor, is a G protein-coupled receptor activated by 5-oxo-eicosatetraenoic acid (5-oxo-ETE), a bioactive lipid derived from arachidonic acid metabolism. OXER1 is expressed primarily in leukocytes, including eosinophils, neutrophils, and macrophages, where it mediates pro-inflammatory and chemotactic responses. Activation of OXER1 triggers pathways such as PI3K/Akt and MAPK, promoting immune cell migration, cytokine production, and oxidative stress responses. OXER1 plays a crucial role in allergic inflammation, asthma, and other eosinophilic diseases, where it contributes to immune cell recruitment to inflamed tissues. In cancer, OXER1 is implicated in tumor progression and metastasis, particularly in prostate and breast cancers, where 5-oxo-ETE signaling enhances cell proliferation and survival. Dysregulation of OXER1 has also been associated with cardiovascular diseases and chronic inflammatory conditions. Given its roles in inflammation and cancer, OXER1 is considered a promising therapeutic target for managing eosinophilic disorders, chronic inflammation, and tumor progression.
Productos relacionados
Oxoeicosanoid Receptor 1 (OXER1) Antibody
OXER1 Antibody is a Rabbit Polyclonal against OXER1.…
Ver producto
Oxoeicosanoid Receptor 1 (OXER1) Antibody
OXER1 Antibody is a Rabbit Polyclonal against OXER1.…
Ver producto Oxoeicosanoid Receptor 1 (OXER1) Antibody (HRP)
OXER1 Antibody (HRP) is a Rabbit Polyclonal against OXER1.…
Ver producto