Orexin Receptor Type 2 (HCRTR2) Antibody
312€ (60 µl)
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name
Orexin Receptor Type 2 (HCRTR2) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx002205
tested applications
WB
Description
HCRTR2 Antibody is a Rabbit Polyclonal antibody against HCRTR2. The protein encoded by this gene is a G-protein coupled receptor involved in the regulation of feeding behavior. The encoded protein binds the hypothalamic neuropeptides orexin A and orexin B. A related gene (HCRTR1) encodes a G-protein coupled receptor that selectively binds orexin A.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Orexin Receptor Type 2 (HCRTR2) |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 60 µl |
| Size 2 | 120 µl |
| Size 3 | 200 µl |
| Form | Liquid |
| Tested Applications | WB |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O43614 |
| Gene ID | 3062 |
| NCBI Accession | NP_001517.2 |
| Alias | HCRTR2,hypocretin receptor 2,orexin receptor type 2,OX2R,OXR2,ORXR2 |
| Background | Antibody anti-HCRTR2 |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
HCRTR2 is a G protein-coupled receptor that binds both orexin-A and orexin-B, neuropeptides that regulate arousal, sleep-wake cycles, and energy balance. HCRTR2 is widely expressed in the hypothalamus, brainstem, and other CNS regions involved in sleep regulation, feeding behavior, and stress responses. HCRTR2 primarily couples to Gq proteins, activating phospholipase C (PLC), increasing intracellular calcium levels, and stimulating pathways such as MAPK and CREB. HCRTR2 plays a vital role in promoting wakefulness and preventing REM sleep, contributing to arousal stability and energy expenditure. Dysregulation of HCRTR2 is strongly linked to narcolepsy type 1, where loss of orexin-producing neurons leads to excessive sleepiness and disrupted sleep architecture. HCRTR2 agonists are being investigated as potential therapies for narcolepsy, while dual orexin receptor antagonists (targeting HCRTR1 and HCRTR2) are used to treat insomnia by promoting sleep onset and maintenance. HCRTR2’s critical role in wakefulness, stress, and metabolism highlights its therapeutic potential in sleep and neuropsychiatric disorders.
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