Human HCRTR2 (Orexin receptor type 2) ELISA Kit

Este producto es parte de HCRTR - Orexin Receptor Type
Product Graph
Contáctenos para saber el precio

Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.

935106861
info@markelab.com
name
Human HCRTR2 (Orexin receptor type 2) ELISA Kit
category
ELISA Kits
provider
FineTest
reference
EH14683
tested applications
ELISA

Documents del producto

Instrucciones
Descargar
Data sheet

Product specifications

Category
ELISA Kits
Reactivity
Human
Detection Method
Colorimetric
Assay Data
4 hours
Assay Type
Sandwich ELISA, Double Antibody
Test Range
31.25-2000pg/ml
Sensitivity
18.75pg/ml
Size 1
96T
Tested Applications
ELISA
Sample Type
Serum, Plasma, Cell Culture Supernatant, cell or tissue lysate, Other liquid samples
Availability
Shipped within 10-14 working days.
Storage
2-8 °C for 12 months
UniProt ID
O43614
Alias
HCRTR2,hypocretin receptor 2,orexin receptor type 2,OX2R,OXR2,ORXR2
Background
Elisa kits for HCRTR2
Status
RUO

HCRTR2 is a G protein-coupled receptor that binds both orexin-A and orexin-B, neuropeptides that regulate arousal, sleep-wake cycles, and energy balance. HCRTR2 is widely expressed in the hypothalamus, brainstem, and other CNS regions involved in sleep regulation, feeding behavior, and stress responses. HCRTR2 primarily couples to Gq proteins, activating phospholipase C (PLC), increasing intracellular calcium levels, and stimulating pathways such as MAPK and CREB. HCRTR2 plays a vital role in promoting wakefulness and preventing REM sleep, contributing to arousal stability and energy expenditure. Dysregulation of HCRTR2 is strongly linked to narcolepsy type 1, where loss of orexin-producing neurons leads to excessive sleepiness and disrupted sleep architecture. HCRTR2 agonists are being investigated as potential therapies for narcolepsy, while dual orexin receptor antagonists (targeting HCRTR1 and HCRTR2) are used to treat insomnia by promoting sleep onset and maintenance. HCRTR2’s critical role in wakefulness, stress, and metabolism highlights its therapeutic potential in sleep and neuropsychiatric disorders.

Related Products

EH14683

Human HCRTR2 (Orexin receptor type 2) ELISA Kit

Ver Producto
abx002205

Orexin Receptor Type 2 (HCRTR2) Antibody

HCRTR2 Antibody is a Rabbit Polyclonal antibody against HCRTR2. The protein encoded by this gene is a G-protein coupled receptor involved in the regulation of feeding behavior. The encoded protein binds the hypothalamic neuropeptides orexin A and orexin B. A related gene (HCRTR1) encodes a G-protein coupled receptor that selectively binds orexin A.

Ver Producto
abx241086

Orexin receptor type 2 (HCRTR2) Antibody

HCRTR2 Antibody is a Rabbit Polyclonal against HCRTR2.

Ver Producto