OPN-a / b Antibody
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935106861
info@markelab.com
Precio
292.5€ (80 µl)
Antibody anti-OPN5
proveedor
Abbexareference
abx026330Tested Applications
ELISA, WB, IHC, IF/ICCreactivity
Humanstatus
RUOclonality
PolyclonalDescripción
Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. Acts as a cytokine involved in enhancing production of interferon-gamma and interleukin-12 and reducing production of interleukin-10 and is essential in the pathway that leads to type I immunity (By similarity).
Background
Opsin-5, also known as OPN5, is a recently discovered opsin protein involved in non-visual light sensing. It belongs to the family of opsins that are sensitive to light but are not involved in traditional vision processes like those in rod and cone cells. OPN5 is thought to play a role in various physiological processes, such as regulating circadian rhythms, influencing mood, and potentially modulating the response to light in certain tissues. Unlike opsins involved in visual photoreception, OPN5 is activated by light in the ultraviolet and blue regions of the spectrum. Its expression has been identified in several tissues, including the brain and skin, where it likely contributes to the body's light-responsive mechanisms. OPN5 may play a role in regulating sleep-wake cycles, similar to melanopsin, but it is less understood. Further research into OPN5's specific functions and its mechanisms of action could provide new insights into how the body processes light outside the visual system and how light exposure affects various biological rhythms and behaviors.
Características del producto
category
Primary Antibodies
clonality
Polyclonal
reactivity
Human
immunogen target
OPN-a/b
host
Rabbit
isotype
IgG
conjugation
Unconjugated
form
Liquid
tested applications
ELISA, WB, IHC, IF/ICC
purification
Purified through a protein A column, followed by peptide affinity purification.
recommended dilution
WB: 1/1000, IHC-P: 1/50 - 1/100, IF/ICC: 1/25. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
buffer
PBS containing 0.09% sodium azide.
size 1
80 µl
size 2
400 µl
storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
or code
OPN5
dry ice
No
availability
Shipped within 5-10 working days.
alias
OPN5,opsin 5,transmembrane protein 13,GPR136,PGR12,neuropsin,PGR14,TMEM13,G protein-coupled receptor 136
uniprot id
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