Opioid Binding Protein/cell Adhesion Molecule Like (OPCML) Antibody
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Description
This gene encodes a member of the IgLON subfamily in the immunoglobulin protein superfamily. The encoded protein is localized in the plasma membrane and may have an accessory role in opioid receptor function. This gene has an ortholog in rat and bovine. The opioid binding-cell adhesion molecule encoded by the rat gene binds opioid alkaloids in the presence of acidic lipids, exhibits selectivity for mu ligands and acts as a GPI-anchored protein. Since the encoded protein is highly conserved in species during evolution, it may have a fundamental role in mammalian systems. Two transcript variants encoding different isoforms have been found for this gene.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Opioid Binding Protein/cell Adhesion Molecule Like (OPCML) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q14982 |
| Alias | OPCM,OBCAM,IGLON1,IgLON family member 1,Opioid-binding cell adhesion molecule |
| Background | Antibody anti-OPCML |
| Status | RUO |
Descripción
Opioid binding protein/cell adhesion molecule-like (OPCML) is a member of the IgLON family of cell adhesion molecules (CAMs), which play essential roles in cell-cell communication and adhesion. OPCML was initially identified due to its ability to bind opioids, which suggested a potential role in the modulation of opioid signaling. However, subsequent research has revealed that its primary function lies in cell adhesion and tumor suppression. OPCML is encoded by the OPCML gene located on chromosome 11q25. This gene is highly conserved across species, indicating its crucial role in cellular processes. OPCML is ubiquitously expressed in various tissues, including the brain, where it participates in neural cell adhesion and signaling. In recent years, OPCML has gained attention due to its tumor suppressor functions and its involvement in several cancers.
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