Nucleotide Binding Oligomerization Domain Containing Protein 2 (NOD2) Antibody
260€ (50 µl)
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935106861
info@markelab.com
name
Nucleotide Binding Oligomerization Domain Containing Protein 2 (NOD2) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx211027
tested applications
ELISA, IHC
Description
NOD2 Antibody is a Rabbit Polyclonal against NOD2.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Nucleotide Binding Oligomerization Domain Containing Protein 2 (NOD2) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | ELISA: 1/2000 - 1/5000, IHC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Antigen Affinity Chromatography. |
| Size 1 | 50 µl |
| Size 2 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, IHC |
| Buffer | PBS, pH 7.4, containing 0.05% NaN3 and 40% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9HC29 |
| Gene ID | 64127 |
| Alias | NOD2, ACUG, BLAU, CARD15, CD, CLR16.3, IBD1, NLRC2, NOD2B, PSORAS1, nucleotide binding oligomerization domain containing 2, BLAUS, YAOS |
| Background | Antibody anti-NOD2 |
| Status | RUO |
Descripción
CARD15, also known as NOD2 (Nucleotide-binding oligomerization domain containing 2), is a member of the NOD-like receptor (NLR) family, which is involved in the innate immune response. CARD15 plays a critical role in detecting bacterial components, such as muramyl dipeptide, which are found in the cell walls of certain bacteria. Upon activation, CARD15 triggers signaling pathways that lead to the activation of NF-κB and MAPK pathways, promoting the production of pro-inflammatory cytokines. This process is crucial for the immune system to respond to bacterial infections. Mutations in CARD15/NOD2 are associated with several diseases, particularly Crohn's disease, a form of inflammatory bowel disease (IBD), highlighting its role in regulating gut immune responses. Disruptions in CARD15 signaling can result in inappropriate immune activation, contributing to chronic inflammation and autoimmune disorders.
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