Nucleotide Binding Oligomerization Domain Containing 2 (NOD2) Antibody
637€ (100 µl)
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935106861
info@markelab.com
name
Nucleotide Binding Oligomerization Domain Containing 2 (NOD2) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx114240
tested applications
ELISA, WB
Description
Nucleotide-Binding Oligomerization Domain Containing 2 Antibody is a Rabbit Polyclonal antibody against Nucleotide-Binding Oligomerization Domain Containing 2.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Nucleotide Binding Oligomerization Domain Containing 2 (NOD2) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Antigen Affinity Chromatography. |
| Size 1 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS, pH 7.3, containing 0.02% Sodium Azide and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9HC29 |
| Gene ID | 64127 |
| NCBI Accession | NP_001280486.1, NM_001293557.1, NP_071445.1, NM_022162.2 |
| OMIM | 186580 |
| Alias | NOD2, ACUG, BLAU, CARD15, CD, CLR16.3, IBD1, NLRC2, NOD2B, PSORAS1, nucleotide binding oligomerization domain containing 2, BLAUS, YAOS |
| Background | Antibody anti-NOD2 |
| Status | RUO |
Descripción
CARD15, also known as NOD2 (Nucleotide-binding oligomerization domain containing 2), is a member of the NOD-like receptor (NLR) family, which is involved in the innate immune response. CARD15 plays a critical role in detecting bacterial components, such as muramyl dipeptide, which are found in the cell walls of certain bacteria. Upon activation, CARD15 triggers signaling pathways that lead to the activation of NF-κB and MAPK pathways, promoting the production of pro-inflammatory cytokines. This process is crucial for the immune system to respond to bacterial infections. Mutations in CARD15/NOD2 are associated with several diseases, particularly Crohn's disease, a form of inflammatory bowel disease (IBD), highlighting its role in regulating gut immune responses. Disruptions in CARD15 signaling can result in inappropriate immune activation, contributing to chronic inflammation and autoimmune disorders.
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