Nucleopurin 62 kDa C-Terminal Like Protein

Background

Nucleoporin 62 C-Terminal Like (NUP62CL) is a protein homologous to the C-terminal domain of NUP62, a key component of the nuclear pore complex (NPC). The NPC is crucial for nucleocytoplasmic transport, facilitating the selective exchange of macromolecules such as RNA and proteins between the nucleus and cytoplasm. While the specific role of NUP62CL is less defined, it is thought to contribute to NPC-associated processes, potentially influencing transport dynamics or structural integrity of the pore complex. Emerging evidence suggests that NUP62CL may have tissue-specific or context-dependent functions, possibly in specialized forms of transport regulation or in the assembly of nuclear pores under specific conditions. Dysregulation of nucleoporins, including NUP62CL, has been implicated in diseases such as cancer and neurodegenerative disorders, highlighting the importance of NPC components in maintaining cellular homeostasis. Further research is needed to uncover the precise biological and pathological roles of NUP62CL.