Nucleoporin 98 kDa (NUP98) Antibody (FITC)
169€ (20 µg)
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Name
Nucleoporin 98 kDa (NUP98) Antibody (FITC)
Category
Primary Antibodies
Provider
Abbexa
Reference
abx336851
Description
NUP98 Antibody (FITC) is a Rabbit Polyclonal against NUP98.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Nucleoporin 98 kDa (NUP98) Immunogen: Recombinant Human Nuclear pore complex protein Nup98-Nup96 protein (965-1110AA). |
| Host | Rabbit |
| Reactivity | Human |
| Detection Method | Laser Line: 488 Excitation/Emission: 499/515 |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | FITC |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G. |
| Size 1 | 20 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid exposure to light. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P52948 |
| Gene ID | 4928 |
| Alias | ADIR2,NUP96,NUP196,Nup98-96,Nuclear pore complex protein Nup98-Nup96, nucleoporin 96,ADAR2 |
| Background | Antibody anti-NUP98 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
Nucleoporin 98 and 96 precursor (NUP98) is an important member of the nuclear pore complex, involved in the regulation of macromolecular trafficking between the nucleus and cytoplasm NUP98 is part of the larger family of nucleoporins that help maintain the structural integrity and function of the nuclear pore complex, ensuring that proteins, RNA, and ribosomal subunits are efficiently transported across the nuclear envelope NUP98, in particular, is involved in the movement of RNA molecules from the nucleus to the cytoplasm, a critical step in gene expression and protein synthesis Additionally, NUP98 plays a role in the regulation of cell division and apoptosis, where it contributes to the proper functioning of the mitotic spindle and the cell cycle Dysregulation of NUP98 has been implicated in various cancers, where it contributes to the aberrant regulation of gene expression and the disruption of nuclear-cytoplasmic communication Mutations in NUP98 are also associated with hematological disorders such as leukemia, highlighting its significance in maintaining normal cellular processes and in disease progression Its role in both structural integrity and molecular trafficking makes NUP98 essential for cellular function and overall organismal health
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