Human Nucleoporin 98 kDa (NUP98) Protein
234€ (10 µg)
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Name
Human Nucleoporin 98 kDa (NUP98) Protein
Category
Proteins and Peptides
Provider
Abbexa
Reference
abx068369
Tested Applications
WB, SDS-PAGE
Description
Human Nucleoporin 98 kDa (NUP98) is a recombinant Human protein expressed in E. coli.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Proteins and Peptides |
| Immunogen Target | Nucleoporin 98kDa (NUP98) |
| Host | E. coli |
| Assay Type | Activity: Not tested Sequence Fragment: Gln629-Pro894 Tag: N-terminal His tag |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Calculated MW: 33.5 kDa Observed MW (SDS-PAGE): 34 kDa |
| Expression | Recombinant |
| Purity | > 90% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: 100 mM NaHCO<sub>3</sub>, 500 mM NaCl, pH 8.3, containing 1 mM EDTA, 1 mM DTT, 0.01% Sarcosyl, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store lyophilized form at 2-8°C for up to 1 month. For longer periods, store lyophilized or liquid at -80°C. Avoid repeated freeze–thaw cycles. |
| Dry Ice | No |
| UniProt ID | P52948 |
| Alias | ADIR2,NUP96,NUP196,Nup98-96,Nuclear pore complex protein Nup98-Nup96, nucleoporin 96,ADAR2 |
| Background | Protein NUP98 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. Reconstitute in ddH2O to a concentration between 0.1-1.0 mg/ml. Do not vortex. Concentration: Prior to lyophilization: 200 µg/ml |
Background
Nucleoporin 98 and 96 precursor (NUP98) is an important member of the nuclear pore complex, involved in the regulation of macromolecular trafficking between the nucleus and cytoplasm NUP98 is part of the larger family of nucleoporins that help maintain the structural integrity and function of the nuclear pore complex, ensuring that proteins, RNA, and ribosomal subunits are efficiently transported across the nuclear envelope NUP98, in particular, is involved in the movement of RNA molecules from the nucleus to the cytoplasm, a critical step in gene expression and protein synthesis Additionally, NUP98 plays a role in the regulation of cell division and apoptosis, where it contributes to the proper functioning of the mitotic spindle and the cell cycle Dysregulation of NUP98 has been implicated in various cancers, where it contributes to the aberrant regulation of gene expression and the disruption of nuclear-cytoplasmic communication Mutations in NUP98 are also associated with hematological disorders such as leukemia, highlighting its significance in maintaining normal cellular processes and in disease progression Its role in both structural integrity and molecular trafficking makes NUP98 essential for cellular function and overall organismal health
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