Nucleoporin 54 kDa (NUP54) Antibody
637€ (100 µl)
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935106861
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name
Nucleoporin 54 kDa (NUP54) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx114229
tested applications
ELISA, WB
Description
Nucleoporin 54 kDa Antibody is a Rabbit Polyclonal antibody against Nucleoporin 54 kDa.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Nucleoporin 54 kDa (NUP54) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Antigen Affinity Chromatography. |
| Size 1 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS, pH 7.3, containing 0.02% Sodium Azide and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q7Z3B4 |
| Gene ID | 53371 |
| NCBI Accession | NP_001265532.1, NM_001278603.1, NP_059122.2, NM_017426.3 |
| OMIM | 607607 |
| Alias | DYT37,nucleoporin 54kDa |
| Background | Antibody anti-NUP54 |
| Status | RUO |
Descripción
Nucleoporin 54 (NUP54) is an essential part of the nuclear pore complex and plays a critical role in the bidirectional transport of molecules between the nucleus and cytoplasm NUP54 interacts with other nucleoporins to form the central channel of the nuclear pore, regulating the selective exchange of macromolecules, such as RNA, ribosomal subunits, and proteins, across the nuclear envelope It is involved in maintaining the structure of the pore complex and ensuring proper nuclear function NUP54 has been linked to various cellular processes, including gene expression, RNA splicing, and cellular signaling, due to its involvement in nuclear-cytoplasmic communication Dysregulation of NUP54 is associated with conditions like cancer, where defective nuclear pore function disrupts the regulation of key proteins and gene expression pathways Additionally, NUP54’s role in cellular stress responses highlights its importance in maintaining cell survival and homeostasis under various physiological conditions
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