Nucleoporin 54 kDa (NUP54) Antibody

Background

Nucleoporin 54 (NUP54) is an essential part of the nuclear pore complex and plays a critical role in the bidirectional transport of molecules between the nucleus and cytoplasm NUP54 interacts with other nucleoporins to form the central channel of the nuclear pore, regulating the selective exchange of macromolecules, such as RNA, ribosomal subunits, and proteins, across the nuclear envelope It is involved in maintaining the structure of the pore complex and ensuring proper nuclear function NUP54 has been linked to various cellular processes, including gene expression, RNA splicing, and cellular signaling, due to its involvement in nuclear-cytoplasmic communication Dysregulation of NUP54 is associated with conditions like cancer, where defective nuclear pore function disrupts the regulation of key proteins and gene expression pathways Additionally, NUP54’s role in cellular stress responses highlights its importance in maintaining cell survival and homeostasis under various physiological conditions