NUP54 antibody
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935106861
info@markelab.com
name
NUP54 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab05926
tested applications
ELISA, WB
Description
Component of the nuclear pore complex, a complex required for the trafficking across the nuclear membrane.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | nucleoporin 54kDa (NUP54) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:500-1:2000 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 55kd |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q7Z3B4 |
| Gene ID | 53371 |
| Alias | DYT37,nucleoporin 54kDa |
| Background | Antibody anti-NUP54 |
| Status | RUO |
| Note | Mol. Weight 55 kDa |
Descripción
Nucleoporin 54 (NUP54) is an essential part of the nuclear pore complex and plays a critical role in the bidirectional transport of molecules between the nucleus and cytoplasm NUP54 interacts with other nucleoporins to form the central channel of the nuclear pore, regulating the selective exchange of macromolecules, such as RNA, ribosomal subunits, and proteins, across the nuclear envelope It is involved in maintaining the structure of the pore complex and ensuring proper nuclear function NUP54 has been linked to various cellular processes, including gene expression, RNA splicing, and cellular signaling, due to its involvement in nuclear-cytoplasmic communication Dysregulation of NUP54 is associated with conditions like cancer, where defective nuclear pore function disrupts the regulation of key proteins and gene expression pathways Additionally, NUP54’s role in cellular stress responses highlights its importance in maintaining cell survival and homeostasis under various physiological conditions
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