Nucleoporin 214 (NUP214) Antibody
312€ (60 µl)
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935106861
info@markelab.com
name
Nucleoporin 214 (NUP214) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx005915
tested applications
IF/ICC
Description
NUP214 Antibody is a Rabbit Polyclonal Antibody against NUP214.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Nucleoporin 214 (NUP214) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | IF/ICC: 1/50 - 1/100. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 60 µl |
| Size 2 | 120 µl |
| Size 3 | 200 µl |
| Form | Liquid |
| Tested Applications | IF/ICC |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P35658 |
| Gene ID | 8021 |
| NCBI Accession | NP_005076.3 |
| Alias | CAN,CAIN,IIAE9,nuclear pore complex protein Nup214,CAN protein, putative oncogene,nucleoporin 214kDa |
| Background | Antibody anti-NUP214 |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
Nucleoporin 214 (NUP214) is a critical component of the nuclear pore complex, contributing to the regulation of nucleocytoplasmic transport NUP214 is involved in the formation of the pore’s central channel, which facilitates the selective exchange of molecules, such as RNA, ribosomal subunits, and proteins, between the nucleus and the cytoplasm It plays a key role in the movement of various signaling proteins and RNA species that regulate cellular processes like gene expression, DNA repair, and cellular stress responses NUP214 also helps ensure the integrity of the nuclear envelope during cell division and is essential for maintaining nuclear function through proper nucleocytoplasmic exchange Dysregulation of NUP214 has been linked to various cancers, where altered nuclear transport contributes to tumorigenesis and metastasis Additionally, NUP214 is associated with certain viral infections, as it can impact the movement of viral components between the nucleus and cytoplasm, influencing the viral replication cycle
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