Mouse Nucleoporin 214 kDa (NUP214) Protein

Este producto es parte de NUP - nucleoporin
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234€ (10 µg)

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935106861
info@markelab.com
name
Mouse Nucleoporin 214 kDa (NUP214) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx167421
tested applications
WB, SDS-PAGE

Description

Mouse Nucleoporin 214 kDa Protein is a recombinant Mouse protein expressed in E. coli.

Documents del producto

Instrucciones
Data sheet
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Product specifications

Category
Proteins and Peptides
Immunogen Target
Nucleoporin 214kDa (NUP214)
Host
E. coli
Origin
Mouse
Conjugation
Unconjugated
Observed MW
Molecular Weight: Calculated MW: 33.6 kDa
Concentration: Prior to lyophilization: 200 µg/ml
Sequence Fragment: Ser601-Arg868
Tag: N-terminal His tag
Expression
Recombinant
Purity
> 95%
Size 1
10 µg
Size 2
50 µg
Size 3
100 µg
Size 4
200 µg
Size 5
500 µg
Form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
Tested Applications
WB, SDS-PAGE
Buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
Availability
Shipped within 5-7 working days.
Storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
Dry Ice
No
Alias
CAN,CAIN,IIAE9,nuclear pore complex protein Nup214,CAN protein, putative oncogene,nucleoporin 214kDa
Background
Protein NUP214
Status
RUO
Note
This product is for research use only.   Not for human consumption, cosmetic, therapeutic or diagnostic use.

Descripción

Nucleoporin 214 (NUP214) is a critical component of the nuclear pore complex, contributing to the regulation of nucleocytoplasmic transport NUP214 is involved in the formation of the pore’s central channel, which facilitates the selective exchange of molecules, such as RNA, ribosomal subunits, and proteins, between the nucleus and the cytoplasm It plays a key role in the movement of various signaling proteins and RNA species that regulate cellular processes like gene expression, DNA repair, and cellular stress responses NUP214 also helps ensure the integrity of the nuclear envelope during cell division and is essential for maintaining nuclear function through proper nucleocytoplasmic exchange Dysregulation of NUP214 has been linked to various cancers, where altered nuclear transport contributes to tumorigenesis and metastasis Additionally, NUP214 is associated with certain viral infections, as it can impact the movement of viral components between the nucleus and cytoplasm, influencing the viral replication cycle

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