Nuclear Receptor Subfamily 1 Group I Member 2 (NR1I2) Antibody
169€ (20 µl)
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Name
Nuclear Receptor Subfamily 1 Group I Member 2 (NR1I2) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx320414
Tested Applications
ELISA, IHC
Description
NR1I2 Antibody is a Rabbit Polyclonal against NR1I2.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Nuclear Receptor Subfamily 1 Group I Member 2 (NR1I2) Immunogen: Recombinant human Nuclear receptor subfamily 1 group I member 2 protein (175-434AA). |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | IHC: 1/20 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Antigen Affinity Chromatography. |
| Size 1 | 20 µl |
| Size 2 | 50 µl |
| Size 3 | 100 µl |
| Size 4 | 200 µl |
| Size 5 | 1 ml |
| Form | Liquid |
| Tested Applications | ELISA, IHC |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O75469 |
| Gene ID | 8856 |
| NCBI Accession | NP_003880.3, NM_003889.3 |
| OMIM | 603065 |
| Alias | BXR,PAR,PRR,PXR,SAR,SXR,ONR1,PAR1,PAR2,PARq,Orphan nuclear receptor PAR1,Orphan nuclear receptor PXR,Orphan nuclear receptor PAR1,Orphan nuclear receptor PXR,Pregnane X receptor |
| Background | Antibody anti-NR1I2 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
Nuclear receptor subfamily 1 group I member 2 (NR1I2), also known as the pregnane X receptor (PXR), is a nuclear receptor that regulates the expression of genes involved in drug metabolism, xenobiotic detoxification, and the transport of various substances PXR is activated by a wide range of compounds, including steroids, bile acids, and pharmaceuticals, and it controls the transcription of genes involved in the metabolism and clearance of these substances It is primarily expressed in the liver, intestine, and kidneys, where it helps protect the body from harmful substances by promoting their elimination PXR also regulates the expression of genes involved in bile acid metabolism, lipid homeostasis, and steroid hormone synthesis Dysregulation of PXR has been associated with drug resistance, liver diseases, and conditions related to altered drug metabolism Its role in detoxification and drug metabolism makes PXR a key target in pharmacology, particularly in managing drug interactions and toxicity
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