Nuclear Receptor Subfamily 1 Group I Member 2 (NR1I2) Antibody
312€ (60 µl)
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935106861
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name
Nuclear Receptor Subfamily 1 Group I Member 2 (NR1I2) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx001333
tested applications
WB, IF/ICC
Description
NR1I2 Antibody is a Rabbit Polyclonal antibody against NR1I2. This gene product belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. The encoded protein is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin. Several alternatively spliced transcripts encoding different isoforms, some of which use non-AUG (CUG) translation initiation codon, have been described for this gene. Additional transcript variants exist, however, they have not been fully characterized.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Nuclear Receptor Subfamily 1 Group I Member 2 (NR1I2) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1/500 - 1/2000, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 60 µl |
| Size 2 | 120 µl |
| Size 3 | 200 µl |
| Form | Liquid |
| Tested Applications | WB, IF/ICC |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O75469 |
| Gene ID | 8856 |
| NCBI Accession | NP_071285.1 |
| Alias | BXR,PAR,PRR,PXR,SAR,SXR,ONR1,PAR1,PAR2,PARq,Orphan nuclear receptor PAR1,Orphan nuclear receptor PXR,Orphan nuclear receptor PAR1,Orphan nuclear receptor PXR,Pregnane X receptor |
| Background | Antibody anti-NR1I2 |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
Nuclear receptor subfamily 1 group I member 2 (NR1I2), also known as the pregnane X receptor (PXR), is a nuclear receptor that regulates the expression of genes involved in drug metabolism, xenobiotic detoxification, and the transport of various substances PXR is activated by a wide range of compounds, including steroids, bile acids, and pharmaceuticals, and it controls the transcription of genes involved in the metabolism and clearance of these substances It is primarily expressed in the liver, intestine, and kidneys, where it helps protect the body from harmful substances by promoting their elimination PXR also regulates the expression of genes involved in bile acid metabolism, lipid homeostasis, and steroid hormone synthesis Dysregulation of PXR has been associated with drug resistance, liver diseases, and conditions related to altered drug metabolism Its role in detoxification and drug metabolism makes PXR a key target in pharmacology, particularly in managing drug interactions and toxicity
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