NR1I3 Cell ELISA Kit
513.5€ (96 tests)
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Name
NR1I3 Cell ELISA Kit
Category
ELISA Kits
Provider
Abbexa
Reference
abx595846
Tested Applications
ELISA
Description
NR1I3 Cell ELISA Kit is a cell-based ELISA Kit. Cells to be assayed should be seeded onto a clear flat bottom 96 well plate, using poly-L-lysine for non-adherent cells. Cells should be grown to 75-90% confluence and treated prior to carrying out the ELISA.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | ELISA Kits |
| Immunogen Target | NR1I3 |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Tested Applications | ELISA |
| Availability | Shipped within 1-2 weeks. |
| Storage | Shipped at 4°C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | Q14994 |
| Gene ID | 9970 |
| OMIM | 603881 |
| Alias | CAR,CAR1,MB67,Constitutive activator of retinoid response,Orphan nuclear receptor MB67 |
| Background | Elisa Kits for: NR1I3 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES. Please note that our kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Background
Nuclear receptor subfamily 1 group I member 3 (NR1I3), also known as the constitutive androstane receptor (CAR), is a nuclear receptor involved in regulating the metabolism of xenobiotics, drugs, and endogenous compounds CAR is activated by various ligands, including drugs, steroids, and bile acids, and it modulates the expression of genes involved in detoxification and drug metabolism It is primarily expressed in the liver, intestine, and kidneys, where it controls the transcription of genes that enhance the metabolism and clearance of toxins, carcinogens, and drugs CAR plays a key role in regulating liver function, bile acid homeostasis, and the metabolism of fatty acids In addition to its role in detoxification, CAR has been implicated in the regulation of inflammation and immune responses Dysregulation of CAR can contribute to liver disease, altered drug metabolism, and drug toxicity, making it an important receptor for understanding drug interactions and developing strategies to manage liver disorders and improve drug safety
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