NR1I3 Antibody is a Rabbit Polyclonal antibody against NR1I3. This gene encodes a member of the nuclear receptor superfamily, and is a key regulator of xenobiotic and endobiotic metabolism. The protein binds to DNA as a monomer or a heterodimer with the retinoid X receptor and regulates the transcription of target genes involved in drug metabolism and bilirubin clearance, such as cytochrome P450 family members. Unlike most nuclear receptors, this transcriptional regulator is constitutively active in the absence of ligand but is regulated by both agonists and inverse agonists. Ligand binding results in translocation of this protein to the nucleus, where it activates or represses target gene transcription. These ligands include bilirubin, a variety of foreign compounds, steroid hormones, and prescription drugs. Multiple transcript variants encoding different isoforms have been found for this gene.
Primary Antibodies
Polyclonal
Human, Mouse, Rat
Constitutive Androstane Receptor / CAR (NR1I3)
Rabbit
Unconjugated
Liquid
WB, IF/ICC
Purified by affinity chromatography.
PBS, pH 7.3, containing 0.01% thimerosal, 50% glycerol.
20 µl
50 µl
100 µl
200 µl
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
NR1I3
No
Shipped within 5-10 working days.
CAR,CAR1,MB67,Constitutive activator of retinoid response,Orphan nuclear receptor MB67
NP_001070948.1
This product is for research use only.
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