Constitutive Androstane Receptor / CAR (NR1I3) Antibody
312€ (60 µl)
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935106861
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name
Constitutive Androstane Receptor / CAR (NR1I3) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx001605
tested applications
WB, IF/ICC
Description
NR1I3 Antibody is a Rabbit Polyclonal antibody against NR1I3. This gene encodes a member of the nuclear receptor superfamily, and is a key regulator of xenobiotic and endobiotic metabolism. The protein binds to DNA as a monomer or a heterodimer with the retinoid X receptor and regulates the transcription of target genes involved in drug metabolism and bilirubin clearance, such as cytochrome P450 family members. Unlike most nuclear receptors, this transcriptional regulator is constitutively active in the absence of ligand but is regulated by both agonists and inverse agonists. Ligand binding results in translocation of this protein to the nucleus, where it activates or represses target gene transcription. These ligands include bilirubin, a variety of foreign compounds, steroid hormones, and prescription drugs. Multiple transcript variants encoding different isoforms have been found for this gene.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Constitutive Androstane Receptor / CAR (NR1I3) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1/500 - 1/2000, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 60 µl |
| Size 2 | 120 µl |
| Size 3 | 200 µl |
| Form | Liquid |
| Tested Applications | WB, IF/ICC |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q14994 |
| Gene ID | 9970 |
| NCBI Accession | NP_001070948.1 |
| Alias | CAR,CAR1,MB67,Constitutive activator of retinoid response,Orphan nuclear receptor MB67 |
| Background | Antibody anti-NR1I3 |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
Nuclear receptor subfamily 1 group I member 3 (NR1I3), also known as the constitutive androstane receptor (CAR), is a nuclear receptor involved in regulating the metabolism of xenobiotics, drugs, and endogenous compounds CAR is activated by various ligands, including drugs, steroids, and bile acids, and it modulates the expression of genes involved in detoxification and drug metabolism It is primarily expressed in the liver, intestine, and kidneys, where it controls the transcription of genes that enhance the metabolism and clearance of toxins, carcinogens, and drugs CAR plays a key role in regulating liver function, bile acid homeostasis, and the metabolism of fatty acids In addition to its role in detoxification, CAR has been implicated in the regulation of inflammation and immune responses Dysregulation of CAR can contribute to liver disease, altered drug metabolism, and drug toxicity, making it an important receptor for understanding drug interactions and developing strategies to manage liver disorders and improve drug safety
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