Constitutive Androstane Receptor / CAR (NR1I3) Antibody (Biotin)
169€ (20 µg)
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935106861
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name
Constitutive Androstane Receptor / CAR (NR1I3) Antibody (Biotin)
category
Primary Antibodies
provider
Abbexa
reference
abx105731
tested applications
ELISA
Description
Nuclear receptor subfamily 1 group I member 3 Antibody (Biotin) is a Rabbit Polyclonal antibody against Nuclear receptor subfamily 1 group I member 3 conjugated to Biotin.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Constitutive Androstane Receptor / CAR (NR1I3) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Biotin |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G. |
| Size 1 | 20 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid exposure to light. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q14994 |
| Gene ID | 9970 |
| NCBI Accession | NP_001070937.1, NM_001077469.2 |
| OMIM | 603881 |
| Alias | CAR,CAR1,MB67,Constitutive activator of retinoid response,Orphan nuclear receptor MB67 |
| Background | Antibody anti-NR1I3 |
| Status | RUO |
Descripción
Nuclear receptor subfamily 1 group I member 3 (NR1I3), also known as the constitutive androstane receptor (CAR), is a nuclear receptor involved in regulating the metabolism of xenobiotics, drugs, and endogenous compounds CAR is activated by various ligands, including drugs, steroids, and bile acids, and it modulates the expression of genes involved in detoxification and drug metabolism It is primarily expressed in the liver, intestine, and kidneys, where it controls the transcription of genes that enhance the metabolism and clearance of toxins, carcinogens, and drugs CAR plays a key role in regulating liver function, bile acid homeostasis, and the metabolism of fatty acids In addition to its role in detoxification, CAR has been implicated in the regulation of inflammation and immune responses Dysregulation of CAR can contribute to liver disease, altered drug metabolism, and drug toxicity, making it an important receptor for understanding drug interactions and developing strategies to manage liver disorders and improve drug safety
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