NPY6R Antibody
169€ (20 µg)
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935106861
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name
NPY6R Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx318792
tested applications
ELISA, WB, IHC, IF/ICC
Description
NPY6R Antibody is a Rabbit Polyclonal against NPY6R.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | NPY6R |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1/500 - 1/5000, IHC: 1/20 - 1/200, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G. |
| Size 1 | 20 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC, IF/ICC |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q99463 |
| Alias | NPY6R,PP2,Y2B,NPY1RL,NPY6RP,Y5,Pancreatic polypeptide receptor 2,PP2 |
| Background | Antibody anti-NPY6R |
| Status | RUO |
Descripción
NPY6R is a non-functional neuropeptide Y receptor in humans due to genetic inactivation; however, it remains functional in certain other species. In functional contexts, NPY6R binds neuropeptide Y (NPY) and peptide YY (PYY), acting as a regulator of energy homeostasis, feeding behavior, and metabolic responses. Its signaling is thought to couple to Gi/o proteins, inhibiting adenylate cyclase and reducing cAMP levels, similar to other NPY receptors. While non-functional in humans, NPY6R’s evolutionary remnants suggest a historical role in appetite and energy regulation. Its absence in humans highlights compensatory mechanisms involving other NPY receptors, such as NPY1R, NPY2R, and NPY5R, which maintain neuropeptide-mediated regulation of feeding, energy balance, and stress responses. Understanding NPY6R’s evolutionary divergence provides insights into species-specific differences in neuropeptide signaling and its role in energy regulation.
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