Nociceptin receptor (OPRL1) Antibody
260€ (50 µl)
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Name
Nociceptin receptor (OPRL1) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx214819
Tested Applications
ELISA, WB
Description
OPRL1 Antibody is a Rabbit Polyclonal against OPRL1.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Nociceptin receptor (OPRL1) Immunogen: Synthetic peptide of human OPRL1. |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | ELISA: 1/1000 - 1/5000, WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Antigen Affinity Chromatography. |
| Size 1 | 50 µl |
| Size 2 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS, pH 7.4, containing 0.05% NaN3 and 40% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P41146 |
| Gene ID | 4987 |
| Alias | OPRL1,N/OFQ receptor,OP4,KOR-3,NOCIR,kappa3-related opioid receptor,MOR-C,nociceptin receptor ORL1,XOR1,NOP-r,nociceptin/orphanin FQ receptor,NOPr,NOP,OOR,NOPr,OPRL,ORL1,PNOCR |
| Background | Antibody anti-OPRL1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
The nociceptin receptor (OPRL1), also known as the opioid receptor-like 1 receptor (ORL1), is a G protein-coupled receptor activated by nociceptin/orphanin FQ, a neuropeptide structurally related to opioid peptides. Unlike classical opioid receptors, OPRL1 does not produce strong analgesic effects when activated. It couples to Gi/o proteins, inhibiting adenylate cyclase, reducing cAMP levels, and modulating ion channels to regulate neuronal excitability. OPRL1 is widely expressed in the central nervous system (CNS), particularly in the brainstem, spinal cord, and limbic regions, where it regulates pain modulation, stress responses, anxiety, and reward behaviors. Activation of OPRL1 can produce anti-analgesic effects, opposing classical opioid analgesia, and plays a critical role in preventing opioid-induced tolerance and dependence. Dysregulation of OPRL1 is associated with chronic pain, drug addiction, and mood disorders. OPRL1 agonists and antagonists are being explored for treating addiction, anxiety, and chronic pain without the side effects of traditional opioids.
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