Neurotrophic Tyrosine Kinase Receptor Type 3 (NTRK3) Antibody
Pida mas información
935106861
info@markelab.com
Precio
362.5€ (100 µl)
Antibody anti-NTRK3
proveedor
Abbexareference
abx015713Tested Applications
ELISAreactivity
Humanstatus
RUOclonality
MonoclonalDescripción
NTRK3 (neurotrophic tyrosine kinase, receptor, type 3), it is a member of the neurotrophic tyrosine receptor kinase (NTRK) family and plays an important role in the development and maintenance of neural tissues.This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway.Signalling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position.Mutations in this gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers.
Background
Neurotrophic receptor tyrosine kinase 3 (NTRK3), also known as TrkC, binds primarily with neurotrophin-3 (NT-3) and is integral to the proper development and function of both the central and peripheral nervous systems. This receptor promotes neuronal survival, axonal growth, and the guidance of neuronal connections during development. Dysfunctions in NTRK3 signaling pathways are linked to developmental disorders, including autism spectrum disorders and some cancers, such as medulloblastomas. Its role in neurodevelopment and oncology continues to be a focus of significant clinical research.
Características del producto
category
Primary Antibodies
clonality
Monoclonal
reactivity
Human
immunogen target
Neurotrophic Tyrosine Kinase Receptor Type 3 (NTRK3)
host
Mouse
conjugation
Unconjugated
form
Liquid
tested applications
ELISA
purification
Unpurified ascites.
buffer
Ascitic fluid containing 0.03% sodium azide.
size 1
100 µl
storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
or code
NTRK3
dry ice
No
availability
Shipped within 5-10 working days.
alias
TRKC,GP145-TrkC,gp145(trkC),TrkC tyrosine kinase,Neurotrophic tyrosine kinase receptor type 3,NT-3 growth factor receptor
uniprot id
note
This product is for research use only.
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