Neuroserpin (SERPINI1) Antibody (FITC)
169€ (20 µg)
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Name
Neuroserpin (SERPINI1) Antibody (FITC)
Category
Primary Antibodies
Provider
Abbexa
Reference
abx317629
Description
SERPINI1 Antibody (FITC) is a Rabbit Polyclonal against SERPINI1 conjugated to FITC.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Neuroserpin (SERPINI1) Immunogen: Recombinant Human Neuroserpin protein (191-240AA). |
| Host | Rabbit |
| Reactivity | Human |
| Detection Method | Laser Line: 488 Excitation/Emission: 499/515 |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | FITC |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G. |
| Size 1 | 20 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid exposure to light. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q99574 |
| Gene ID | 5274 |
| OMIM | 602445 |
| Alias | PI12,HNS-S1,HNS-S2,neuroserpin,Peptidase inhibitor 12,Serpin I1 |
| Background | Antibody anti-SERPINI1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
SERPINI1 (serpin family I member 1) is a gene encoding the neuroserpin protein, a member of the serpin (serine protease inhibitor) superfamily. Unlike many other serpins, neuroserpin is primarily expressed in the central nervous system, where it plays a critical role in regulating proteolytic activity, particularly by inhibiting tissue-type plasminogen activator (tPA). The balance between neuroserpin and tPA is crucial for neural development, synaptic plasticity, and maintaining the integrity of neuronal tissues. SERPINI1 mutations are associated with certain neurodegenerative diseases, notably familial encephalopathy with neuroserpin inclusion bodies (FENIB), a condition characterized by the accumulation of misfolded neuroserpin proteins in neurons. This leads to neurodegeneration, progressive cognitive decline, and other neurological impairments.
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