Neuropeptide Y Receptor Y2 (NPY2R) Antibody
52€ (10 µg)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
935106861
info@markelab.com
name
Neuropeptide Y Receptor Y2 (NPY2R) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx015351
tested applications
ELISA, WB, IF/ICC
Description
Rabbit polyclonal antibody against NPY2R protein.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Neuropeptide Y Receptor Y2 (NPY2R) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1/500 - 1/3000, IF/ICC: 1/100 - 1/500, ELISA: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen. |
| Size 1 | 10 µg |
| Size 2 | 100 µg |
| Size 3 | 200 µg |
| Size 4 | 300 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IF/ICC |
| Buffer | PBS (without Mg<sup>2+</sup> and Ca<sup>2+</sup>), pH 7.4, 150 mM NaCl, 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P49146 |
| Gene ID | 4887 |
| OMIM | 162642 |
| Alias | NPY2R,NPY2-R,neuropeptide Y receptor type 2,NPY-Y2 receptor |
| Background | Antibody anti-NPY2R |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
NPY2R is a G protein-coupled receptor that binds neuropeptide Y (NPY) and peptide YY (PYY) with high affinity. NPY2R is predominantly expressed in the central nervous system (CNS), particularly in the hypothalamus, hippocampus, and brainstem, as well as in peripheral tissues such as the gastrointestinal tract. It functions as an autoreceptor to inhibit the release of NPY and modulates appetite suppression, energy homeostasis, and gastrointestinal motility. NPY2R couples to Gi/o proteins, reducing adenylate cyclase activity, cAMP levels, and neurotransmitter release. Activation of NPY2R reduces food intake and promotes energy expenditure, making it a key target for anti-obesity therapies. It also plays roles in neuroprotection, stress regulation, and cardiovascular function. Dysregulation of NPY2R signaling is associated with metabolic disorders, anxiety, and inflammatory conditions. NPY2R agonists are being developed to treat obesity by enhancing satiety and energy expenditure, highlighting its role as a critical regulator of feeding behavior and metabolism.
Related Products
Human NPYR2 (Neuropeptide Y Receptor Y2) ELISA Kit
Ver Producto
Neuropeptide Y Receptor Y2 (NPY2R) Antibody
Rabbit polyclonal antibody against NPY2R protein.
Ver Producto
Neuropeptide Y Receptor Y2 (NPY2R) Antibody
Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is PYY > NPY > PYY (3-36) > NPY (2-36) > [Ile-31, Gln-34] PP > [Leu-31, Pro-34] NPY > PP, [Pro-34] PYY and NPY free acid.
Ver Producto