Neuronal Cell Adhesion Molecule (NrCAM) Antibody (PerCP)

Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Description
NrCAM Antibody is a Mouse Monoclonal against NrCAM.
Documents del producto
Product specifications
Category | Primary Antibodies |
Immunogen Target | Neuronal Cell Adhesion Molecule (NrCAM) |
Host | Mouse |
Reactivity | Human, Mouse, Rat |
Recommended Dilution | WB: 1/1000, IF/ICC: 1/100. Optimal dilutions/concentrations should be determined by the end user. |
Clonality | Monoclonal |
Conjugation | PerCP |
Isotype | IgG2a |
Purification | Purified by Protein G. |
Size 1 | 100 µg |
Tested Applications | WB, IF/ICC |
Buffer | PBS, pH 7.4, 50% glycerol, 0.1% sodium azide. |
Availability | Please enquire. |
Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
Dry Ice | No |
UniProt ID | Q810U4 |
Gene ID | 319504 |
NCBI Accession | NP_001139503.1 |
Alias | NEDNMS,NgCAM-related cell adhesion molecule,Nr-CAM,Neuronal surface protein Bravo |
Background | Antibody anti-NRCAM |
Status | RUO |
Note | Concentration: 1 mg/ml - |
Descripción
Neuronal Cell Adhesion Molecule (NRCAM) is a member of the L1 family of cell adhesion molecules (CAMs), which play a crucial role in the development and function of the nervous system. NRCAM is encoded by the NRCAM gene located on chromosome 7q31. It is predominantly expressed in the nervous system but also found in other tissues. NRCAM mediates cell-cell interactions through homophilic (NRCAM to NRCAM) and heterophilic (NRCAM to other molecules) binding, facilitating processes such as axon guidance, synaptic formation, and maintenance, as well as cellular migration. It is integral to the formation of neural circuits and the establishment of functional connectivity within the brain.
Related Products

anti- NRCAM antibody
Cell adhesion protein that is required for normal responses to cell-cell contacts in brain and in the peripheral nervous system. Plays a role in neurite outgrowth in response to contactin binding. Plays a role in mediating cell-cell contacts between Schwann cells and axons. Plays a role in the formation and maintenance of the nodes of Ranvier on myelinated axons. Nodes of Ranvier contain clustered sodium channels that are crucial for the saltatory propagation of action potentials along myelinated axons. During development, nodes of Ranvier are formed by the fusion of two heminodes. Required for normal clustering of sodium channels at heminodes; not required for the formation of mature nodes with normal sodium channel clusters. Required, together with GLDN, for maintaining NFASC and sodium channel clusters at mature nodes of Ranvier.
Ver Producto
Neuronal Cell Adhesion Molecule (NRCAM) Antibody
Cell adhesion molecules (CAMs) are members of the immunoglobulin superfamily.This gene encodes a neuronal cell adhesion molecule with multiple immunoglobulin-like C2-type domains and fibronectin type-III domains.This ankyrin-binding protein is involved in neuron-neuron adhesion and promotes directional signaling during axonal cone growth.This gene is also expressed in non-neural tissues and may play a general role in cell-cell communication via signaling from its intracellular domain to the actin cytoskeleton during directional cell migration.Allelic variants of this gene have been associated with autism and addiction vulnerability.Alternative splicing results in multiple transcript variants encoding different isoforms.
Ver Producto
Neuronal Cell Adhesion Molecule (NRCAM) Antibody
Neuronal Cell Adhesion Molecule Antibody is a Rabbit Polyclonal antibody against Neuronal Cell Adhesion Molecule.
Ver Producto