Neuronal Cell Adhesion Molecule (NRCAM) Antibody
383.5€ (100 µl)
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Name
Neuronal Cell Adhesion Molecule (NRCAM) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx015947
Tested Applications
ELISA, IF/ICC
Description
Cell adhesion molecules (CAMs) are members of the immunoglobulin superfamily.This gene encodes a neuronal cell adhesion molecule with multiple immunoglobulin-like C2-type domains and fibronectin type-III domains.This ankyrin-binding protein is involved in neuron-neuron adhesion and promotes directional signaling during axonal cone growth.This gene is also expressed in non-neural tissues and may play a general role in cell-cell communication via signaling from its intracellular domain to the actin cytoskeleton during directional cell migration.Allelic variants of this gene have been associated with autism and addiction vulnerability.Alternative splicing results in multiple transcript variants encoding different isoforms.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Neuronal Cell Adhesion Molecule (NRCAM) Immunogen: Purified recombinant fragment of human NRCAM (AA: 1192-1255) expressed in E. coli. |
| Host | Mouse |
| Reactivity | Human |
| Assay Type | Concentration: 1 mg/ml |
| Recommended Dilution | ELISA: 1/10000, IF/ICC: 1/50. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG1 |
| Observed MW | 144 kDa |
| Purification | Purified from ascites by Protein G chromatography. |
| Size 1 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, IF/ICC |
| Buffer | PBS, containing 0.05% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q92823 |
| Gene ID | 4897 |
| OMIM | 601581 |
| Alias | NEDNMS,NgCAM-related cell adhesion molecule,Nr-CAM,Neuronal surface protein Bravo |
| Background | Antibody anti-NRCAM |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
Neuronal Cell Adhesion Molecule (NRCAM) is a member of the L1 family of cell adhesion molecules (CAMs), which play a crucial role in the development and function of the nervous system. NRCAM is encoded by the NRCAM gene located on chromosome 7q31. It is predominantly expressed in the nervous system but also found in other tissues. NRCAM mediates cell-cell interactions through homophilic (NRCAM to NRCAM) and heterophilic (NRCAM to other molecules) binding, facilitating processes such as axon guidance, synaptic formation, and maintenance, as well as cellular migration. It is integral to the formation of neural circuits and the establishment of functional connectivity within the brain.
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