Neurofascin (NFASC) Antibody
195€ (20 µl)
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Name
Neurofascin (NFASC) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx002202
Tested Applications
ELISA, WB
Description
NFASC Antibody is a Rabbit Polyclonal antibody against NFASC. This gene encodes an L1 family immunoglobulin cell adhesion molecule with multiple IGcam and fibronectin domains. The protein functions in neurite outgrowth, neurite fasciculation, and organization of the axon initial segment (AIS) and nodes of Ranvier on axons during early development. Both the AIS and nodes of Ranvier contain high densities of voltage-gated Na+ (Nav) channels which are clustered by interactions with cytoskeletal and scaffolding proteins including this protein, gliomedin, ankyrin 3 (ankyrin-G), and betaIV spectrin. This protein links the AIS extracellular matrix to the intracellular cytoskeleton. This gene undergoes extensive alternative splicing, and the full-length nature of some variants has not been determined.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Neurofascin (NFASC) Immunogen: Recombinant protein corresponding to NFASC. The exact sequence is proprietary. |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Assay Type | Concentration: > 0.2 mg/ml |
| Recommended Dilution | ELISA: 1 µg/ml, WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | Calculated MW: 150 kDa Observed MW: 150 kDa |
| Purification | Purified by affinity chromatography. |
| Size 1 | 20 µl |
| Size 2 | 100 µl |
| Size 3 | 2 × 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O94856 |
| Gene ID | 23114 |
| NCBI Accession | NP_001005388.2 |
| Alias | NF,NRCAML,NEDCPMD,KIAA0756 |
| Background | Antibody anti-NFASC |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
Neurofascin (NFASC) is a cell adhesion molecule crucial for the development and maintenance of the nervous system. It is part of the L1 family of cell adhesion molecules, which are integral membrane proteins involved in cell-cell adhesion processes. Neurofascin plays a pivotal role in the formation and function of the nodes of Ranvier and the initial segments of axons, both of which are critical for the proper conduction of electrical impulses along neurons. The NFASC gene, located on chromosome 1q32.1, encodes several isoforms of neurofascin through alternative splicing. These isoforms have distinct but overlapping functions in neural development and synaptic plasticity.
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