Neurofascin (NFASC) Antibody

Name: Neurofascin (NFASC) Antibody
Brand: Abbexa
SKU: abx002202
Price: 175 EUR
Availability: OnlineOnly

Este producto es parte de NFASC - neurofascin

Pida mas información

935106861

info@markelab.com

Precio

175€ (20 µl)

Antibody anti-NFASC

proveedor

Abbexa

reference

abx002202

Tested Applications

reactivity

Human, Mouse, Rat

status

RUO

clonality

Polyclonal

Descripción

NFASC Antibody is a Rabbit Polyclonal antibody against NFASC. This gene encodes an L1 family immunoglobulin cell adhesion molecule with multiple IGcam and fibronectin domains. The protein functions in neurite outgrowth, neurite fasciculation, and organization of the axon initial segment (AIS) and nodes of Ranvier on axons during early development. Both the AIS and nodes of Ranvier contain high densities of voltage-gated Na+ (Nav) channels which are clustered by interactions with cytoskeletal and scaffolding proteins including this protein, gliomedin, ankyrin 3 (ankyrin-G), and betaIV spectrin. This protein links the AIS extracellular matrix to the intracellular cytoskeleton. This gene undergoes extensive alternative splicing, and the full-length nature of some variants has not been determined.

Background

Neurofascin (NFASC) is a cell adhesion molecule crucial for the development and maintenance of the nervous system. It is part of the L1 family of cell adhesion molecules, which are integral membrane proteins involved in cell-cell adhesion processes. Neurofascin plays a pivotal role in the formation and function of the nodes of Ranvier and the initial segments of axons, both of which are critical for the proper conduction of electrical impulses along neurons. The NFASC gene, located on chromosome 1q32.1, encodes several isoforms of neurofascin through alternative splicing. These isoforms have distinct but overlapping functions in neural development and synaptic plasticity.

Características del producto

clonality

Polyclonal

reactivity

Human, Mouse, Rat

immunogen target

Neurofascin (NFASC)

host

Rabbit

conjugation

Unconjugated

form

Liquid

tested applications

purification

Purified by affinity chromatography.

buffer

PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.

size 1

20 µl

size 2

50 µl

size 3

100 µl

size 4

200 µl

storage

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.

or code

NFASC

dry ice

availability

Shipped within 5-10 working days.

alias

NF,NRCAML,NEDCPMD,KIAA0756

uniprot id

https://www.uniprot.org/uniprotkb/O94856

gene id

https://www.ncbi.nlm.nih.gov/gene/23114

NCBI accession

NP_001005388.2

note

This product is for research use only.

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