Neuregulin 1 (NRG1) Antibody
292.5€ (80 µl)
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name
Neuregulin 1 (NRG1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx032738
tested applications
ELISA, IHC, FCM
Description
Neuregulin 1 (NRG1) was originally identified as a 44-kD glycoprotein that interacts with the NEU/ERBB2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues. It is known that an extraordinary variety of different isoforms are produced from the NRG1 gene by alternative splicing. These isoforms include heregulins (HRGs), glial growth factors (GGFs) and sensory and motor neuron-derived factor (SMDF). They are tissue-specifically expressed and differ significantly in their structure. The HRG isoforms all contain immunoglobulin (Ig) and epidermal growth factor-like (EGF-like) domains. GGF and GGF2 isoforms contain a kringle-like sequence plus Ig and EGF-like domains; and the SMDF isoform shares only the EGF-like domain with other isoforms. The receptors for all NRG1 isoforms are the ERBB family of tyrosine kinase transmembrane receptors. Through interaction with ERBB receptors, NRG1 isoforms induce the growth and differentiation of epithelial, neuronal, glial, and other types of cells.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Neuregulin 1 (NRG1) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | IHC-P: 1/50 - 1/100, FCM: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, IHC, FCM |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q02297 |
| NCBI Accession | NP_001153467.1, NP_001153471.1, NP_001153473.1, NP_001153477.1, NP_001153480.1, NP_039250.2, NP_039251.2, NP_039252.2, NP_039253.1, NP_039254.1, NP_039256.2, NP_039258.1 |
| Alias | GGF,HGL,HRG,NDF,ARIA,GGF2,HRG1,HRGA,SMDF,MST131,MSTP131,NRG1-IT2,Pro-NRG1,Pro-neuregulin-1 membrane-bound isoform,Acetylcholine receptor-inducing activity,Breast cancer cell differentiation factor p45 |
| Background | Antibody anti-NRG1 |
| Status | RUO |
Descripción
Neuregulin 1 (NRG1) is a pivotal signaling protein within the neuregulin family, recognized for its extensive roles in mediating cell-cell communication across various tissues, particularly the nervous system, cardiac muscle, and epithelial structures. This protein functions as a ligand for ErbB receptor tyrosine kinases, thereby regulating processes such as neuronal differentiation, synaptic development, and myelination of nerve fibers. In cardiac tissue, NRG1 is indispensable for heart development and plays a role in maintaining the function and repair of adult cardiac cells. Dysregulation of NRG1 signaling pathways has been linked to a range of pathological conditions, including schizophrenia, various types of cancer, and heart disease, underscoring its biological and therapeutic importance.
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