Myotubularin-Related Protein 5 (SBF1) Antibody

Product specifications

Primary Antibodies

Myotubularin-Related Protein 5 (SBF1)

Rabbit

Human, Rat

ELISA: 1 µg/ml, WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.

Polyclonal

Unconjugated

IgG

Purified by affinity chromatography.

20 µl

100 µl

2 × 100 µl

Liquid

ELISA, WB

PBS, pH 7.3, containing 0.01% thimerosal, 50% glycerol.

Shipped within 5-10 working days.

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.

No

O95248

6305

NP_002963.2

MTMR5,CMT4B3,DENND7A,SET-binding factor 1Inactive phosphatidylinositol 3-phosphatase 5 ,Myotubularin-related protein 5

Antibody anti-SBF1

RUO

Concentration: > 0.2 mg/ml - 

Descripción

SBF1, also known as SET-binding factor 1, is a pseudophosphatase that is structurally related to the myotubularin family of phosphoinositide phosphatases but lacks enzymatic activity due to mutations in its active site. Instead, SBF1 functions as a scaffolding protein involved in various cellular signaling pathways, particularly those regulating cell growth, differentiation, and cytoskeletal organization. It is implicated in membrane trafficking and endosomal sorting processes, often in association with its partner protein, SBF2. SBF1 has been shown to interact with the SET domain of histone-modifying enzymes, suggesting a role in epigenetic regulation, though its precise mechanisms remain under investigation. It is widely expressed in human tissues, with high expression levels in the nervous system and muscle, reflecting its potential roles in neuronal signaling and muscle function. Mutations or dysregulation of SBF1 have been linked to Charcot-Marie-Tooth disease, a hereditary peripheral neuropathy, highlighting its significance in maintaining neuronal integrity. Structural studies have revealed conserved domains responsible for protein-protein interactions, allowing SBF1 to act as a molecular hub in signaling pathways. Functional analyses suggest that SBF1 modulates growth factor receptor signaling, particularly pathways involving PI3K-AKT and Ras, contributing to its role in cell survival and proliferation. Emerging evidence indicates that SBF1 may also regulate autophagy and intracellular trafficking, although these roles require further confirmation.

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