Family main features
SET binding factor (SBF) is a protein that interacts with the SET domain, a key motif in various proteins involved in chromatin modification and transcriptional regulation. SBF plays a significant role in the regulation of gene expression, impacting various cellular processes including cell growth, differentiation, and apoptosis. Understanding the molecular mechanisms involving SBF is critical, as dysregulation can lead to various diseases, including cancer. SBF’s interaction with SET domain-containing proteins is crucial for its role in modulating chromatin structure and function, thereby influencing gene expression patterns in response to cellular signals.
SBF is characterized by several distinct domains that facilitate its interaction with SET domain-containing proteins and other cellular components. The primary structure includes a SET domain binding motif which is essential for its interaction with SET domain proteins. Additionally, SBF contains nuclear localization signals (NLS) that direct it to the nucleus where it exerts its function. The exact amino acid sequence and structural conformation of SBF are critical for its binding affinity and specificity to SET domains. Detailed structural studies, including X-ray crystallography and NMR, have provided insights into the three-dimensional arrangement of these domains, highlighting the importance of specific residues in protein-protein interactions.
SBF can be classified based on its domain architecture and functional interactions:
SBF is primarily involved in the regulation of gene expression through its interaction with SET domain-containing proteins. It modulates chromatin structure by influencing the activity of histone methyltransferases, which are critical for the addition of methyl groups to histones, thereby regulating transcriptional activity. SBF also plays roles in:
Aberrations in SBF function or expression can lead to several clinical conditions:
SET binding factor (SBF) is a critical regulator of gene expression, primarily through its interaction with SET domain-containing proteins involved in chromatin modification. Its structure, featuring a SET domain binding motif and nuclear localization signals, is essential for its function in modulating chromatin and influencing various cellular processes. SBF plays significant roles in cell cycle regulation, apoptosis, and differentiation. Dysregulation of SBF is associated with numerous clinical conditions, including cancer, developmental disorders, and neurodegenerative diseases, highlighting its importance in maintaining cellular homeostasis. Understanding the precise mechanisms of SBF function and regulation can provide insights into therapeutic targets for these diseases.
SET binding factor 1 (SBF1)
MTMR5,CMT4B3,DENND7A,SET-binding factor 1Inactive phosphatidylinositol 3-phosphatase 5 ,Myotubularin-related protein 5
SET binding factor 2 (SBF2)
CMT4B2,MTMR13,DENND7B,SET-binding factor 2,Inactive phosphatidylinositol 3-phosphatase 13,Myotubularin-related protein 13
En la tabla siguiente se muestra una comparativa de todos los reactivos disponibles en nuestro catálogo (ELISA Kits, Primary Antibodies) relacionados con SBF - SET binding factor
Se muestran ordenados por categorías para poder comparar cómodamente sus características principales. Esta tabla, que contiene un enlace con la ficha de cada producto, es exportable a Excel.
Esta página contiene 8 reactivos de las marcas (Abbexa, FineTest) que se corresponden con tu busqueda
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provider | Code | reference | name | reactivity | sample type | assay type | test range | sensitivity | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | SBF1 | abx533932 | Human Myotubularin-related protein 5 (SBF1) ELISA Kit | Human | Tissue homogenates,Cell lysates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | O95248 | RUO | ||
Abbexa | SBF2 | abx533950 | Human Myotubularin-related protein 13 (SBF2) ELISA Kit | Human | Tissue homogenates,Cell lysates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | Q86WG5 | RUO | ||
Abbexa | SBF1 | abx533933 | Mouse Myotubularin-related protein 5 (SBF1) ELISA Kit | Mouse | Tissue homogenates,Cell lysates,Other biological fluids | 0.312 ng/ml - 20 ng/ml | < 0.13 ng/ml | 687.5 | 96 tests | Q6ZPE2 | RUO |
provider | Code | reference | name | reactivity | clonality | host | immunogen target | isotype | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | SBF1 | abx126512 | Myotubularin-Related Protein 5 (SBF1) Antibody | Human | Polyclonal | Rabbit | Myotubularin-Related Protein 5 (SBF1) | Unconjugated | WB | 175 | 20 µl | O95248 | RUO | |
Abbexa | SBF2 | abx313531 | Myotubularin-Related Protein 13 (SBF2) Antibody (HRP) | Human | Polyclonal | Rabbit | Myotubularin-Related Protein 13 (SBF2) | HRP | ELISA | 162.5 | 20 µg | Q86WG5 | RUO | |
Abbexa | SBF2 | abx313532 | Myotubularin-Related Protein 13 (SBF2) Antibody (FITC) | Human | Polyclonal | Rabbit | Myotubularin-Related Protein 13 (SBF2) | FITC | 162.5 | 20 µg | Q86WG5 | RUO | ||
Abbexa | SBF2 | abx313530 | Myotubularin-Related Protein 13 (SBF2) Antibody | Human | Polyclonal | Rabbit | Myotubularin-Related Protein 13 (SBF2) | Unconjugated | ELISA, IHC, IF/ICC | 162.5 | 20 µg | Q86WG5 | RUO | |
Abbexa | SBF2 | abx313533 | Myotubularin-Related Protein 13 (SBF2) Antibody (Biotin) | Human | Polyclonal | Rabbit | Myotubularin-Related Protein 13 (SBF2) | Biotin | ELISA | 162.5 | 20 µg | Q86WG5 | RUO |
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