Myosin Light Chain Kinase 4 (MYLK4) Antibody
292.5€ (80 µl)
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935106861
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name
Myosin Light Chain Kinase 4 (MYLK4) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx032677
tested applications
ELISA, WB, IHC
Description
MYLK4 Antibody is a Rabbit Polyclonal antibody against MYLK4.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Myosin Light Chain Kinase 4 (MYLK4) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1/1000, IHC-P: 1/50 - 1/100. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q86YV6 |
| Alias | SgK085,Sugen kinase 85,Myosin light chain kinase family member 4 |
| Background | Antibody anti-MYLK4 |
| Status | RUO |
Descripción
Myosin Light Chain Kinase 4 (MYLK4) is a member of the myosin light chain kinase (MLCK) family, which are serine/threonine protein kinases that phosphorylate myosin light chains (MLC) to regulate actomyosin contractility and cytoskeletal dynamics. MYLK4, like other MYLK family members, plays a role in cellular processes involving actin-myosin interactions, including cell movement, shape maintenance, and intracellular transport. Structurally, MYLK4 contains kinase domains that share homology with other MLCKs but has notable differences in regulatory regions, including the lack of calmodulin-binding motifs typically found in other family members. This suggests MYLK4 might have a calcium-independent regulation mechanism, distinguishing it from classic MLCKs like MYLK1. MYLK4 is expressed in various tissues, including the skeletal muscle, brain, and reproductive organs, suggesting its involvement in diverse biological functions. Emerging evidence indicates its role in cytoskeletal remodeling, which is critical for processes like neuronal development and muscle maintenance. MYLK4’s expression in non-muscle tissues points to additional, less-defined regulatory roles in cellular signaling pathways.
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