Myosin-Binding Protein H (MYBPH) Antibody
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935106861
info@markelab.com
Precio
250€ (80 µl)
Antibody anti-MYBPH
proveedor
Abbexareference
abx029727Tested Applications
ELISA, WBreactivity
Humanstatus
RUOclonality
PolyclonalDescripción
MYBPH binds to myosin; probably involved in interaction with thick myofilaments in the A-band.
Background
Myosin Binding Protein H (MYBPH) is a member of the myosin-binding protein family, which are crucial for regulating muscle contraction and sarcomere organization in striated muscles. MYBPH primarily interacts with thick filaments, specifically the myosin filaments, contributing to the stabilization and structural integrity of the sarcomere, the fundamental contractile unit of muscle fibers. Structurally, MYBPH contains immunoglobulin-like (Ig-like) domains, which facilitate its binding to myosin and other sarcomeric proteins. These domains allow MYBPH to regulate the alignment and interaction of thick filaments within the sarcomere. MYBPH is primarily expressed in striated muscles, particularly in cardiac and skeletal muscles, suggesting its role in maintaining the functional architecture of these tissues. Functionally, MYBPH plays a role in modulating muscle contraction and fine-tuning sarcomere mechanics. By interacting with myosin heavy chains, MYBPH can influence the efficiency and stability of actomyosin interactions during contraction. Mutations or alterations in MYBPH expression have been linked to certain muscle disorders, including cardiomyopathies and other skeletal muscle dysfunctions, where sarcomere disorganization occurs.
Características del producto
category
Primary Antibodies
clonality
Polyclonal
reactivity
Human
immunogen target
Myosin-Binding Protein H (MYBPH)
host
Rabbit
conjugation
Unconjugated
form
Liquid
tested applications
ELISA, WB
purification
Purified through a protein A column, followed by peptide affinity purification.
buffer
PBS containing 0.09% sodium azide.
size 1
80 µl
size 2
400 µl
storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
or code
MYBPH
dry ice
No
availability
Shipped within 5-10 working days.
alias
MyBP-H,H-protein
uniprot id
note
This product is for research use only.
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