Myosin-Binding Protein H (MYBPH) Antibody

Este producto es parte de MYBPH - myosin binding protein H ( LIKE)
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292.5€ (80 µl)

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935106861
info@markelab.com
name
Myosin-Binding Protein H (MYBPH) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx029727
tested applications
ELISA, WB

Description

MYBPH binds to myosin; probably involved in interaction with thick myofilaments in the A-band.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Primary Antibodies
Immunogen Target
Myosin-Binding Protein H (MYBPH)
Host
Rabbit
Reactivity
Human
Recommended Dilution
WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Clonality
Polyclonal
Conjugation
Unconjugated
Isotype
IgG
Purification
Purified through a protein A column, followed by peptide affinity purification.
Size 1
80 µl
Size 2
400 µl
Form
Liquid
Tested Applications
ELISA, WB
Buffer
PBS containing 0.09% sodium azide.
Availability
Shipped within 5-10 working days.
Storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
Q13203
Gene ID
4608
OMIM
160795
Alias
MyBP-H,H-protein
Background
Antibody anti-MYBPH
Status
RUO

Descripción

Myosin Binding Protein H (MYBPH) is a member of the myosin-binding protein family, which are crucial for regulating muscle contraction and sarcomere organization in striated muscles. MYBPH primarily interacts with thick filaments, specifically the myosin filaments, contributing to the stabilization and structural integrity of the sarcomere, the fundamental contractile unit of muscle fibers.  Structurally, MYBPH contains immunoglobulin-like (Ig-like) domains, which facilitate its binding to myosin and other sarcomeric proteins. These domains allow MYBPH to regulate the alignment and interaction of thick filaments within the sarcomere. MYBPH is primarily expressed in striated muscles, particularly in cardiac and skeletal muscles, suggesting its role in maintaining the functional architecture of these tissues. Functionally, MYBPH plays a role in modulating muscle contraction and fine-tuning sarcomere mechanics. By interacting with myosin heavy chains, MYBPH can influence the efficiency and stability of actomyosin interactions during contraction. Mutations or alterations in MYBPH expression have been linked to certain muscle disorders, including cardiomyopathies and other skeletal muscle dysfunctions, where sarcomere disorganization occurs.

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