Multidrug Resistance Associated Protein 9 (ABCC12) Antibody
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Description
This gene is a member of the superfamily of ATP-binding cassette (ABC) transporters and the encoded protein contains two ATP-binding domains and 12 transmembrane regions. ABC proteins transport various molecules across extra and intracellular membranes. ABC genes are divided into seven distinct subfamilies: ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White. This gene is a member of the MRP subfamily which is involved in multi-drug resistance. This gene and another subfamily member are arranged head-to-tail on chromosome 16q12.1. Increased expression of this gene is associated with breast cancer.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Multidrug Resistance Associated Protein 9 (ABCC12) |
| Host | Rabbit |
| Reactivity | Mouse |
| Recommended Dilution | WB: 1/2000, IHC-P: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q80WJ6 |
| Gene ID | 244562 |
| Alias | MRP9,ATP-binding cassette sub-family C member 12 |
| Background | Antibody anti-ABCC12 |
| Status | RUO |
Descripción
ABCC12, a member of the ABCC subfamily, is a membrane-associated transporter protein implicated in multidrug resistance and cellular detoxification processes. Its expression is observed in various tissues, including the testis and breast. Although its exact substrates and biological functions remain under investigation, ABCC12 may contribute to transporting organic anions or xenobiotics. Dysregulation or mutations in ABCC12 have potential links to cancer progression and drug resistance. Further research is essential to elucidate its precise physiological and pathological roles.
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