Multidrug Resistance Associated Protein 9 (ABCC12) Antibody
292.5€ (80 µl)
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Name
Multidrug Resistance Associated Protein 9 (ABCC12) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx027270
Tested Applications
ELISA, WB, IHC
Description
This gene is a member of the superfamily of ATP-binding cassette (ABC) transporters and the encoded protein contains two ATP-binding domains and 12 transmembrane regions. ABC proteins transport various molecules across extra and intracellular membranes. ABC genes are divided into seven distinct subfamilies: ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White. This gene is a member of the MRP subfamily which is involved in multi-drug resistance. This gene and another subfamily member are arranged head-to-tail on chromosome 16q12.1. Increased expression of this gene is associated with breast cancer.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Multidrug Resistance Associated Protein 9 (ABCC12) Immunogen: KLH-conjugated synthetic peptide between 723-752 amino acids from the Central region of human ABCC12. |
| Host | Rabbit |
| Reactivity | Mouse |
| Recommended Dilution | WB: 1/2000, IHC-P: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | Calculated MW: 152 kDa |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q80WJ6 |
| Gene ID | 244562 |
| Alias | MRP9,ATP-binding cassette sub-family C member 12 |
| Background | Antibody anti-ABCC12 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
ABCC12, a member of the ABCC subfamily, is a membrane-associated transporter protein implicated in multidrug resistance and cellular detoxification processes. Its expression is observed in various tissues, including the testis and breast. Although its exact substrates and biological functions remain under investigation, ABCC12 may contribute to transporting organic anions or xenobiotics. Dysregulation or mutations in ABCC12 have potential links to cancer progression and drug resistance. Further research is essential to elucidate its precise physiological and pathological roles.
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