Mouse UBX domain-containing protein 1 (UBXN1) ELISA Kit
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935106861
info@markelab.com
Precio
715€ (96 tests)
Elisa kits for UBXN1
proveedor
Abbexareference
abx552427Tested Applications
ELISAreactivity
Mousestatus
RUOclonality
Descripción
Mouse UBX Domain-Containing Protein 1 (UBXN1) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Mouse UBX Domain-Containing Protein 1 concentrations in tissue homogenates, cell lysates and other biological fluids.
Background
UBX domain protein 1 (UBXN1) is a ubiquitin regulatory protein containing a UBX domain, which enables its interaction with p97/VCP, a key ATPase involved in protein degradation and cellular quality control UBXN1 functions as a cofactor for p97, participating in the extraction and degradation of misfolded proteins during endoplasmic reticulum-associated degradation (ERAD) It regulates protein homeostasis by linking p97 to the ubiquitin-proteasome system and autophagy pathways UBXN1 is also involved in DNA damage repair, where it regulates protein turnover at replication forks and facilitates chromatin remodeling Dysregulation of UBXN1 impairs protein clearance, contributing to neurodegenerative diseases such as Alzheimer’s and Parkinson’s, where protein aggregates accumulate in neurons Emerging studies also connect UBXN1 to cancer biology, as it influences protein turnover in tumor cells and regulates apoptosis Its role in maintaining proteostasis and cellular stress responses underscores its importance in cellular quality control mechanisms
Características del producto
category
ELISA Kits
immunogen target
UBX Domain-Containing Protein 1 (UBXN1)
reactivity
Mouse
test range
0.156 ng/ml - 10 ng/ml
assay type
Sandwich
assay data
Quantitative
form
Lyophilized
detection method
Colorimetric
sample type
Tissue homogenates, cell lysates and other biological fluids.
size 1
96 tests
alias
2B28,SAKS1,UBXD10,SAPK substrate protein 1,UBA/UBX 33.3 kDa protein
storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
or code
UBXN1
dry ice
No
uniprot id
note
This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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