Mouse Ubiquitin Carboxyl Terminal Hydrolase L4 (UCHL4) Protein

Background

Ubiquitin C-Terminal Hydrolase L4 (UCHL4) is a member of the deubiquitinating enzyme family, which plays a critical role in the ubiquitin-proteasome system by removing ubiquitin moieties from ubiquitinated proteins. This process regulates protein degradation, turnover, and signaling pathways. UCHL4 is specifically involved in maintaining cellular ubiquitin homeostasis, thus influencing various cellular processes, including cell cycle progression, DNA repair, and stress responses. Dysregulation of UCHL4 activity has been implicated in pathological conditions such as cancer, where it may affect the stability of key oncogenes or tumor suppressors. Additionally, UCHL4 might have a role in neurodegenerative diseases through its function in protein quality control and aggregation prevention. Understanding its precise biological mechanisms is essential for exploring its potential as a therapeutic target in diseases associated with ubiquitin pathway dysregulation.