Mouse Ubiquitin carboxyl-terminal hydrolase isozyme L3 (UCHL3) ELISA Kit
715€ (96 tests)
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935106861
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name
Mouse Ubiquitin carboxyl-terminal hydrolase isozyme L3 (UCHL3) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx552443
tested applications
ELISA
Description
Mouse Ubiquitin carboxyl-terminal hydrolase isozyme L3 (UCHL3) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Mouse Ubiquitin carboxyl-terminal hydrolase isozyme L3 concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Ubiquitin carboxyl-terminal hydrolase isozyme L3 (UCHL3) |
| Reactivity | Mouse |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-15 working days. The validity for this kit is 6 months. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | Q9JKB1 |
| Gene ID | 50933 |
| Alias | UCH-L3,Ubiquitin thioesterase L3 |
| Background | Elisa kits for UCHL3 |
| Status | RUO |
| Note | Validity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
UCHL3 is a deubiquitinating enzyme involved in ubiquitin recycling and protein turnover, ensuring cellular protein quality control and homeostasis. It cleaves ubiquitin precursors and removes ubiquitin chains from target proteins, preventing their premature degradation by the proteasome. UCHL3 is ubiquitously expressed and plays roles in DNA repair, apoptosis, and embryonic development. It is particularly essential for spermatogenesis, where it regulates chromatin remodeling and germ cell differentiation. Loss of UCHL3 function is associated with impaired cellular proteostasis, genomic instability, and reproductive defects. Studies show its involvement in tumor progression, where dysregulation of UCHL3 alters protein degradation pathways, contributing to cancer cell survival. Knockout models exhibit defects in germ cell development, growth retardation, and increased sensitivity to cellular stress, underscoring its importance in ubiquitin regulation, cellular stability, and reproductive biology.
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