Mouse Tyrosine-Protein Kinase Mer (MERTK) Protein (Active)
923€ (50 µg)
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935106861
info@markelab.com
name
Mouse Tyrosine-Protein Kinase Mer (MERTK) Protein (Active)
category
Proteins and Peptides
provider
Abbexa
reference
abx693622
tested applications
SDS-PAGE
Description
Mouse MERTK Protein is a recombinant protein from Mouse produced in Baculovirus-Insect Cells. A DNA sequence encoding the mouse MERTK (Q60805) (Glu573-Tyr867) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Tyrosine-Protein Kinase Mer (MERTK) |
| Host | Insect |
| Origin | Mouse |
| Observed MW | Molecular Weight: 61.7 kDa Sequence Fragment: Glu573-Tyr867 Tag: N-terminal His tag and GST tag Validity: The validity for this protein is 6 months. |
| Expression | Recombinant |
| Purity | > 96% (SDS-PAGE) |
| Size 1 | 50 µg |
| Form | |
| Tested Applications | SDS-PAGE |
| Buffer | Supplied as sterile 20mM Tris, 500mM NaCl, pH 7.4, 10% gly. |
| Availability | Shipped within 5-15 working days. |
| Storage | Aliquot and store at -20°C or -80°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q60805 |
| Gene ID | 17289 |
| Alias | MER,RP38,c-Eyk,c-mer,Tyro12,Receptor tyrosine kinase MerTK,Proto-oncogene c-Mer |
| Background | Protein MERTK |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
MERTK (MER Proto-Oncogene, Tyrosine Kinase) is a member of the TAM (TYRO3, AXL, and MERTK) receptor tyrosine kinase family, which plays a crucial role in the regulation of immune response, cell survival, migration, and phagocytosis. This gene was identified due to its homology with the avian oncogene v-Mer and is involved in the clearance of apoptotic cells and immune tolerance. The MERTK protein is primarily expressed in macrophages, dendritic cells, and retinal pigment epithelial cells. Dysregulation of MERTK has been implicated in various diseases, including cancer, autoimmune disorders, and retinal degenerative diseases.
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