Mouse Tyrosine-Protein Kinase Mer (MERTK) Protein (Active)
975€ (50 µg)
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Name
Mouse Tyrosine-Protein Kinase Mer (MERTK) Protein (Active)
Category
Proteins and Peptides
Provider
Abbexa
Reference
abx693622
Tested Applications
SDS-PAGE
Description
Tyrosine-Protein Kinase Mer (MERTK) protein is a recombinant Mouse protein expressed in Insect.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Proteins and Peptides |
| Immunogen Target | Tyrosine-Protein Kinase Mer (MERTK) |
| Host | Insect |
| Assay Type | Activity: Active Sequence Fragment: Glu573-Tyr867 Tag: N-terminal His tag and GST tag |
| Origin | Mouse |
| Observed MW | 61.7 kDa |
| Expression | Recombinant |
| Purity | > 96% (SDS-PAGE) |
| Size 1 | 50 µg |
| Form | Liquid |
| Tested Applications | SDS-PAGE |
| Buffer | 20 mM Tris, 500 mM NaCl, pH 7.4, 10% glycerol. |
| Availability | Shipped within 5-15 working days. |
| Storage | Aliquot and store at -20 °C. Avoid repeated freeze/thaw cycles. Shelf Life: 6 months. |
| Dry Ice | No |
| UniProt ID | Q60805 |
| Gene ID | 17289 |
| Alias | MER,RP38,c-Eyk,c-mer,Tyro12,Receptor tyrosine kinase MerTK,Proto-oncogene c-Mer |
| Background | Protein MERTK |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. Endotoxin Level: < 1.0 EU per µg (LAL method). |
Background
MERTK (MER Proto-Oncogene, Tyrosine Kinase) is a member of the TAM (TYRO3, AXL, and MERTK) receptor tyrosine kinase family, which plays a crucial role in the regulation of immune response, cell survival, migration, and phagocytosis. This gene was identified due to its homology with the avian oncogene v-Mer and is involved in the clearance of apoptotic cells and immune tolerance. The MERTK protein is primarily expressed in macrophages, dendritic cells, and retinal pigment epithelial cells. Dysregulation of MERTK has been implicated in various diseases, including cancer, autoimmune disorders, and retinal degenerative diseases.
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